This $326,797 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) aims to identify proteomic (protein-based) biomarkers that can predict risk of cognitive impairment in individuals with type 2 diabetes. The primary goal is to use proteomic analyses to discover plasma protein differences and networks associated with newly diagnosed mild cognitive impairment in this population. The project will also examine how these proteins relate to preclinical...
The National Institute on Aging (NIA) awarded a $429,000 Project Grant (CFDA 93.866 - Aging Research) to Northeast Ohio Medical University (Neomed) to evaluate the role of acetylation on brain proteome dynamics in a mouse model of Alzheimer's Disease (AD) and type 2 diabetes mellitus (T2DM). The 2-year project aims to quantify proteome and acetylome dynamics in the hippocampus and frontal cortex of diet-induced diabetic and non-diabetic AD mice to determine the effect of T2DM-related...
This Project Grant award of $152,400 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a study to characterize the associations between intraindividual cognitive variability (IICV), longitudinal changes in magnetic resonance imaging (MRI) measures related to Alzheimer's disease and Alzheimer's disease-related dementia (AD/ADRD), and diabetes among older American Indians. The study aims to: 1) examine whether IICV is associated with neurodegenerative-related MRI...
This $834,094 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to advance research on post-stroke cognitive impairment and dementia (PSCID). The funding will support a multi-year effort leveraging a national stroke registry and Medicare data to determine the incidence and prevalence of PSCID, identify associated risk factors, and explore potential pharmacological prevention strategies. Key aspects of the research include a patient-centered approach,...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to New York University School of Medicine provides $254,250 to develop a biologically relevant multi-scale model of brain aging using advanced diffusion MRI (dMRI) techniques. The goal is to create a brain microstructure age framework that provides insights into the processes underlying brain aging and Alzheimer's disease/related dementias (AD/ADRD). The award period runs from Sep 15, 2024 to Jun...
The National Institute on Aging (NIA) awarded a $1,161,852 project grant under the Aging Research (CFDA 93.866) program to Wayne State University (WSU) to investigate the neuroprotective properties of the drug canagliflozin and its potential to improve cognitive function during aging. The project will assess canagliflozin's effects on neuroinflammation, insulin responsiveness, and cognitive performance in aged mice, including mouse models of Alzheimer's disease. WSU is collaborating with The...
This $3,845,311 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866) to the University of California, San Diego (UCSD). The award aims to use induced neurons (iNs) derived from mild cognitive impairment (MCI) patients to investigate the early determinants and pathogenesis of Alzheimer's disease (AD). The project will integrate polygenic risk scores for AD with multi-omic profiling of MCI patient-derived iNs to better understand the...
This Project Grant award from the National Institute of Neurological Disorders and Stroke (NINDS), under the Extramural Research Programs in the Neurosciences and Neurological Disorders (CFDA 93.853) program, will support research to investigate the role of complement-mediated inflammation in exacerbating stroke outcomes in mice with type 2 diabetes. The $604,795 award, effective from December 1, 2024 to November 30, 2029, will enable the Northern California Institute for Research and Education,...
This $200,323 federal Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) will support research by the University of South Florida to investigate the aggregation of amyloid-beta (Aβ) peptides during metabolic stress and spreading depolarization events in the brain. The project will utilize multiscale modeling, high-resolution microscopy, antibody staining, and paralysis phenotype testing in C. elegans to determine how physiochemical changes...
This Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) for $2,273,637 aims to conduct a comprehensive lipidomics study to investigate the relationship between plasma and brain lipid profiles, cognitive decline, and the onset of Alzheimer's disease (AD) and other dementias. The study will leverage the Cardiovascular Health Study cohort to examine the association of plasma lipidomic species with risks of incident AD, total dementia, and cognitive decline. It...