The federal Project Grant award titled "Communicating Heath Advancements from Native Genetics Research (CHANGE Research)" is being provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The $519,740 grant will fund a multi-method study to assess American Indian and Alaska Native (AI/AN) perceptions and knowledge of Alzheimer's disease and related dementias (ADRD) research, with a focus on biomarkers. The research team at Washington State...
This Project Grant award, valued at $2,380,018.00, was provided by the National Institute on Aging (CFDA 93.866 - Aging Research) to the Regents of the University of Michigan. The overarching goal is to investigate the influence of cumulative hyperglycemia, type 2 diabetes management, and vascular risk factors on cognitive decline and Alzheimer's disease and related dementias (ADRD) risk. The research team will leverage pooled cohort studies and individual participant data meta-analysis to...
This Project Grant award, valued at $350,881 and issued by the National Institute on Aging (CFDA 93.866 Aging Research), aims to investigate plasma-based neuronal insulin signaling (NIS) exosomes as a potential biomarker for cognitive impairment in patients with diabetes mellitus (DM). The grantee, Hennepin Healthcare Research Institute, will leverage data from the existing ACCORD-MIND study to analyze NIS exosomes isolated from blood samples of 200 DM patients with varying glycemic control. The...
This $326,797 Project Grant award from the National Institute on Aging's Aging Research program (CFDA 93.866) aims to identify proteomic (protein-based) biomarkers that can predict risk of cognitive impairment in individuals with type 2 diabetes. The primary goal is to use proteomic analyses to discover plasma protein differences and networks associated with newly diagnosed mild cognitive impairment in this population. The project will also examine how these proteins relate to preclinical...
This Project Grant award, funded by the National Institute on Aging (CFDA 93.866 Aging Research), supports a multi-domain (genetic, socio-behavioral, vascular) study to investigate risk factors and prediction of Alzheimer's disease (AD) and related dementias (ADRD) among middle-aged South Asians in India. The $12,847,914 award to Emory University will leverage the existing Precision-CARRS cohort to perform AD/ADRD phenotyping, characterize genetic risk, and develop machine learning models to...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $2,251,070 to the University of California Irvine through July 2025. The grant supports research to develop new statistical methodologies for analyzing Alzheimer's disease data from longitudinal cohort studies. Key deliverables include methods for assessing prediction precision for recurrent event survival data using time-dependent ROC and C-index...
This $2,365,042 Project Grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to conduct research on the biological underpinnings of Alzheimer's disease and related dementias (ADRD). The research aims to better characterize the interplay between biological markers of neurodegeneration, vascular, nutritional, and inflammatory systems, and their interface with social and economic factors, by leveraging cross-national comparisons...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $640,906 to the University of Wisconsin - Madison to elucidate cerebrovascular disease pathways contributing to cognitive decline. The 5-year project, effective June 1, 2025, aims to leverage advanced neuroimaging techniques to characterize dynamic vascular and hemodynamic factors, such as intracranial vascular stiffness and neurovascular flow tone, that may impact brain tissue integrity and...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $164,648 to Trustees of Indiana University (Indianapolis) to investigate the role of the fractalkine axis in Alzheimer's disease pathology using human induced pluripotent stem cells. The central goal is to utilize human iPSCs to study the impact of the CX3CR1 V249I variant on microglial function and whether this variant induces a neurodegenerative phenotype in neurons. The research aims to...
This $839,262 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a multilevel investigation into the effects of migration on the risk of Alzheimer's disease and related dementias (ADRD) among Mexican Americans. Conducted by the Trustees of Columbia University, the study will leverage a unique binational dataset to (1) estimate the impact of migration, US residence, and acculturation on cognitive function and dementia risk, (2) evaluate how...