This $784,596 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Northeastern University supports a comprehensive and cell type-specific proteogenomic profiling study of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The goal is to improve understanding of AD's causes and identify new therapeutic targets by globally profiling disease-associated proteins with amino acid substitutions, alternative isoforms,...
This $326,797 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) aims to use proteomic analyses to identify proteins associated with newly diagnosed mild cognitive impairment in people with type 2 diabetes. The primary goal is to reveal potential mechanisms underlying cognitive impairment syndromes in this population, with the intent of identifying plasma-derived protein biomarkers for risk stratification and possible therapeutic targets. The award includes...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,119,771 in funding to the University of Massachusetts Medical School to study the role of peripheral insulin resistance and inflammation in the development of Alzheimer's disease (AD). The research will define age-related changes in metabolism and inflammation in peripheral organs and the brain during AD-relevant neurodegeneration, and delineate the connection between liver insulin...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will provide $2,380,018 to the Regents of the University of Michigan to conduct research on the impact of type 2 diabetes and prediabetes on cognitive decline and Alzheimer's disease risk. The key products and services to be delivered include: Quantifying the influence of cumulative hyperglycemia from young adulthood to late life on cognitive trajectories and Alzheimer's disease...
This $372,400 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research federal grant program (CFDA 93.866) will support a research study conducted by Nova Southeastern University to evaluate the therapeutic potential of three compounds - tirzepatide, retatrutide, and crocetin - in mitigating Alzheimer's-like pathology in a mouse model of Alzheimer's disease comorbid with obesity and prediabetes. The study aims to assess the impact of these interventions on...
The National Institute on Aging awarded a $480,536 Project Grant under the Aging Research program (CFDA 93.866) to The Jackson Laboratory to fund research aimed at improving treatment for Alzheimer's disease and related dementias (ADRD). The project will assess whether manipulating the angiopoietin/tie2 (ANG/TIE2) signaling pathway can preserve blood-brain barrier (BBB) integrity and prevent cerebrovascular dysfunction, which are major contributors to many ADRDs. The research approach involves...
This $795,436 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a study to elucidate the role of the glycoproteome in Alzheimer's disease and related dementias (AD/ADRD). The study will leverage novel resources, including annual clinical measures, indices of 10 AD/ADRD pathologies, proteome, glycoproteome, and whole genome sequencing data from 800 decedents. The research aims to identify glycopeptiforms related to AD/ADRD pathologies and...
The National Institute on Aging (NIA) awarded a $640,895 Project Grant (CFDA 93.866 - Aging Research) to the University of Wisconsin-Madison to characterize a novel mouse model exhibiting Braak stage I/II Alzheimer's disease (AD) pathology. The goal is to develop this mouse mutant into a new animal model for AD research to help elucidate the underlying mechanisms of tauopathy, amyloidosis, and neuroinflammation - the three hallmarks of the disease. The researchers will determine the spatial...
This $6,226,692 project grant was awarded by the National Institute on Aging (NIA) under the Aging Research Federal Grant Program (CFDA 93.866) to The Trustees of Columbia University in the City of New York. The grant will support research examining the role of neuronal hyperexcitability and proteostasis (regulation of protein life cycle) in the early progression of Alzheimer's disease (AD). The study aims to track electrophysiological changes and protein accumulation in the locus coeruleus...
This federal Project Grant award of $479,375 from the National Institute on Aging (CFDA 93.866 - Aging Research) to Florida International University aims to investigate the effect of a small molecule activator of autophagy, TPI-132, on insulin signaling, senescence, and neuropathology in mouse models of Alzheimer's disease. The key objectives are to: 1) Optimize the potency, brain permeability, and toxicity profile of TPI-132 analogues, 2) Evaluate the selected analogues in primary neurons...