The National Institute on Aging (NIA) awarded a $1,161,852 project grant under the Aging Research (CFDA 93.866) program to Wayne State University (WSU) to investigate the neuroprotective properties of the drug canagliflozin and its potential to improve cognitive function during aging. The project will assess canagliflozin's effects on neuroinflammation, insulin responsiveness, and cognitive performance in aged mice, including mouse models of Alzheimer's disease. WSU is collaborating with The University of Texas Health Science Center at San Antonio (UTHSCSA) to conduct specialized laboratory analyses to measure canagliflozin concentrations in brain tissues, and with the Oklahoma Medical Research Foundation (OMRF) to perform molecular analyses of gene expression related to inflammation. The project aims to validate canagliflozin as a potential therapeutic for preventing or treating age-related cognitive decline and neurodegenerative diseases.
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