Project Grant R03AG088803
Award Date
8/1/24
Completion Date
5/31/26
Dollars Obligated
$327K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Aurora, CO 80045, USA
Similar Awards
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) will provide $2,380,018 to the Regents of the University of Michigan to conduct research on the impact of type 2 diabetes and prediabetes on cognitive decline and Alzheimer's disease risk. The key products and services to be delivered include: Quantifying the influence of cumulative hyperglycemia from young adulthood to late life on cognitive trajectories and Alzheimer's disease...
This $795,436 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a study to elucidate the role of the glycoproteome in Alzheimer's disease and related dementias (AD/ADRD). The study will leverage novel resources, including annual clinical measures, indices of 10 AD/ADRD pathologies, proteome, glycoproteome, and whole genome sequencing data from 800 decedents. The research aims to identify glycopeptiforms related to AD/ADRD pathologies and...
This $784,596 Project Grant awarded by the National Institute on Aging (CFDA 93.866 - Aging Research) to Northeastern University supports a comprehensive and cell type-specific proteogenomic profiling study of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The goal is to improve understanding of AD's causes and identify new therapeutic targets by globally profiling disease-associated proteins with amino acid substitutions, alternative isoforms,...
This Project Grant award from the National Institute on Aging's Aging Research Federal Grant Program (CFDA 93.866) provides $212,816 to the Hennepin Healthcare Research Institute to investigate the use of plasma-based neuronal insulin signaling exosomes as a biomarker for cognitive impairment in diabetes. The project aims to leverage existing data from the ACCORD-MIND study to examine whether impaired neuronal insulin signaling precedes brain volume loss and cognitive decline in adults with...
This federal Project Grant award of $2,554,069 from the National Institute on Aging (CFDA 93.866 - Aging Research) will support a comprehensive study to identify brain metabolic pathways associated with cognitive decline and dementia. Led by an early-stage investigator at Brigham & Women's Hospital, the research will leverage existing and newly-generated brain metabolomic data from over 1,800 metabolites across 1,200 deceased participants from two community-based aging cohorts. The study...
The National Institute on Aging (NIA) awarded a $429,000 Project Grant (CFDA 93.866 - Aging Research) to Northeast Ohio Medical University (Neomed) to evaluate the role of acetylation on brain proteome dynamics in a mouse model of Alzheimer's Disease (AD) and type 2 diabetes mellitus (T2DM). The 2-year project aims to quantify proteome and acetylome dynamics in the hippocampus and frontal cortex of diet-induced diabetic and non-diabetic AD mice to determine the effect of T2DM-related...
This $15,046,454 project grant from the National Institutes of Health National Institute on Aging, under the Aging Research program (CFDA 93.866), will fund research at the University of California, San Diego to improve understanding of proteomic changes preceding Alzheimer's disease and related dementias. The research will analyze longitudinal plasma samples from 2,836 women in the Women's Health Initiative Memory Study cohort using the Somamscan proteomics platform to identify novel...
The National Institute on Aging (NIA) awarded a $2,494,096 Project Grant (CFDA 93.866 - Aging Research) to Brigham & Women's Hospital Inc. to develop a web-based platform for early detection and sensitive tracking of cognitive changes related to Alzheimer's disease (AD). The project aims to leverage a multi-day learning curve assessment to identify diminished learning as an early indicator of preclinical AD. In Aim 1, the researchers will develop a summary score from this assessment and...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $2,119,771 in funding to the University of Massachusetts Medical School to study the role of peripheral insulin resistance and inflammation in the development of Alzheimer's disease (AD). The research will define age-related changes in metabolism and inflammation in peripheral organs and the brain during AD-relevant neurodegeneration, and delineate the connection between liver insulin...
The National Institute on Aging (NIA) awarded a $441,612 Project Grant under the Aging Research federal grant program (CFDA 93.866) to Trustees of Boston University, doing business as Boston University Medical Campus. The grant, effective May 15, 2025 through January 31, 2030, will leverage the Framingham Heart Study's digital cognitive data to evaluate the relationship between the Life's Essential 8 metrics for modifiable risk factors and digital cognitive markers for early detection of...