Project Grant R15DA062121
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
- This federal Project Grant award of $650,250 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting research to investigate the neural mechanisms underlying motivational and cognitive deficits associated with opioid withdrawal. The project aims to uncover the role of dopamine and acetylcholine signaling, as well as the activity of striatal projection neurons, in mediating withdrawal-induced reductions in motivation and...
- This $1,039,420 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to study the neuronal ensembles and circuits involved in the facilitation and disinhibition of opioid and alcohol seeking behaviors. The 5-year project, which begins on June 1, 2025 and runs through February 28, 2030, will employ innovative techniques such as single-nucleus RNA sequencing, spatial sequencing, and in vivo...
- This federal Project Grant award of $390,687 was provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), to New York University (NYU) for a research project titled "CRCNS: MULTIREGIONAL COMPUTATIONS FOR VALUE-BASED DECISION-MAKING". The project aims to characterize how the orbitofrontal cortex (OFC), dorsal striatum (DSTR), and basolateral amygdala (BLA) brain regions interact to support belief updating and...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the CFDA program "Drug Use and Addiction Research Programs" (93.279), will support research to uncover the neurophysiological signatures within the addiction circuitry related to acute opioid use. The $159,711 award, effective January 1, 2025 through December 31, 2029, will leverage a unique ability to directly record local field potentials from awake humans with implanted brain electrodes. This will...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $1,351,034 to the University of Alabama at Birmingham (UAB) to study the role of somatostatin-expressing interneurons in the prelimbic region of the rodent medial prefrontal cortex and their involvement in natural and drug reward seeking behaviors. The award, with a project period from Apr 15, 2025...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $127,401 to investigate the neural mechanisms underlying opioid withdrawal-induced anxiety. The University of Colorado is the awardee, and the research will utilize behavioral animal models and advanced neurotechnological techniques to study how opioid withdrawal impacts dopamine and glutamate signaling in the midbrain-striatal pathway...
- This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
- This federal Project Grant award of $248,717 from the National Institute on Drug Abuse (NIDA), under CFDA program 93.279 - Drug Use and Addiction Research Programs, supports research to investigate the neural circuits and mechanisms underlying orbitofrontal cortex signaling during learning. The project aims to test the hypothesis that the formation of integrated representations in the orbitofrontal cortex depends on activity in chemosensory, motor, and limbic areas, and that orbitofrontal cortex...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the Drug Use and Addiction Research Programs (CFDA 93.279), provides $787,594.00 to the Icahn School of Medicine at Mount Sinai to conduct research on the "Cortical Mechanisms of Opioid Reinforcement." The research aims to better understand the molecular, cellular, and circuit-based mechanisms underlying opioid use disorder (OUD). Specifically, the study will investigate the role of a specialized...
This federal Project Grant award of $476,496.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at American University investigating the role of opioid signaling in reward-guided decision-making within the rat prefrontal cortex. The project, led by the Principal Investigator, will utilize intra-cortical pharmacology, computational modeling, and video analysis to examine how cortical opioid receptors and endogenous enkephalins modulate decision-making. Additionally, the research will investigate the relationship between opioid signaling and medial frontal theta oscillations, a neural marker for cognitive control. The project is designed to actively engage neuroscience majors at American University, who will participate in experiments and contribute to computational data analyses. The award has a performance period from August 15, 2025 to July 31, 2028.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $476.5k | 8/1/25 |