Project Grant R01DA064341
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $127,401 to investigate the neural mechanisms underlying opioid withdrawal-induced anxiety. The University of Colorado is the awardee, and the research will utilize behavioral animal models and advanced neurotechnological techniques to study how opioid withdrawal impacts dopamine and glutamate signaling in the midbrain-striatal pathway...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
- This federal Project Grant award for $340,000 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research to better understand the role of the locus coeruleus-noradrenergic (LC-NE) system in fentanyl withdrawal-induced negative affect behaviors. The research aims to determine whether a newly identified midbrain glutamatergic input to the LC contributes to the negative affective behaviors associated with opioid withdrawal....
- This $1,039,420 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to study the neuronal ensembles and circuits involved in the facilitation and disinhibition of opioid and alcohol seeking behaviors. The 5-year project, which begins on June 1, 2025 and runs through February 28, 2030, will employ innovative techniques such as single-nucleus RNA sequencing, spatial sequencing, and in vivo...
- This federal Project Grant award of $476,496.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at American University investigating the role of opioid signaling in reward-guided decision-making within the rat prefrontal cortex. The project, led by the Principal Investigator, will utilize intra-cortical pharmacology, computational modeling, and video analysis to examine how cortical opioid receptors...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the Drug Use and Addiction Research Programs (CFDA 93.279), provides $787,594.00 to the Icahn School of Medicine at Mount Sinai to conduct research on the "Cortical Mechanisms of Opioid Reinforcement." The research aims to better understand the molecular, cellular, and circuit-based mechanisms underlying opioid use disorder (OUD). Specifically, the study will investigate the role of a specialized...
- This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
- This Project Grant award of $1,485,691 was provided by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, under the Drug Use and Addiction Research Programs (CFDA 93.279). The funding will support research to evaluate the neural correlates and behavioral impact of withdrawal-induced hyperalgesia (increased pain sensitivity) among people who smoke, with and without chronic pain. Specifically, the research aims to: 1) Assess the impact of smoking withdrawal...
- This federal Project Grant award for $613,017.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to examine the interdependent neural circuit mechanisms underlying the timing of dopamine reward omission signals and striatal dynamics in mice. The project, conducted by the University of California, Los Angeles (UCLA), aims to elucidate how dopamine and striatal timing processes interact to enable...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is providing $903,965 to the University of Alabama at Birmingham (UAB) to conduct research on prefrontal circuits controlling heroin seeking behavior. The project aims to identify two functionally opposing prefrontal subcircuits that drive versus limit opioid seeking, with a focus on understanding the role of the infralimbic prefrontal cortex...
This federal Project Grant award of $650,250 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting research to investigate the neural mechanisms underlying motivational and cognitive deficits associated with opioid withdrawal. The project aims to uncover the role of dopamine and acetylcholine signaling, as well as the activity of striatal projection neurons, in mediating withdrawal-induced reductions in motivation and impaired goal-directed action selection. The research, conducted by the University of California Irvine, will utilize advanced behavioral analysis, microdialysis, and optical techniques in rodents to better understand the neurobiological basis of these withdrawal-induced impairments. The long-term goal is to inform the development of strategies to promote abstinence and recovery from opioid use disorders. The award has an initial period of performance from Sep 1, 2025 to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $0 | 9/18/25 | ||
| Not listed | $650.3k | 8/29/25 |