The University of Miami was awarded a $267,310 Project Grant from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant, awarded on September 13, 2024, supports research to assess the functional role of calcitonin gene-related peptide (CGRP) expressing neurons within the parabrachial nucleus (CGRPPBN) in opioid reinforcement and withdrawal. The research aims to determine the gene expression and epigenetic changes associated with...
The National Institute on Drug Abuse (NIDA), through the Drug Use and Addiction Research Programs (CFDA 93.279), awarded a $267,310 Project Grant to the Regents of the University of Minnesota to investigate the role of the neuropeptide VGF and its derived peptide TLQP-62 in regulating synaptic plasticity in the nucleus accumbens and their contribution to opioid withdrawal behaviors. The project aims to use electrophysiology, neuroanatomical mapping, and behavioral assays to understand how VGF...
This $601,612 Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the role of the habenula-interpeduncular nucleus (IPN) circuit in the development of opioid tolerance and withdrawal. The project will use viral approaches, ribosome profiling, and calcium imaging in mice to examine gene expression changes and neuronal activity in the IPN in response to chronic oxycodone exposure. The...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will provide $284,040 to The Lieber Institute for Brain Development to conduct research on the molecular and circuit-level changes in the habenula brain region associated with opioid exposure. The study aims to generate a spatially-resolved atlas of opioid-induced gene expression changes in the rodent habenula at the cellular and circuit level, and to...
This federal Project Grant award, valued at $1,478,199.00 and funded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to investigate the differential roles of prefrontal cortical interneurons in drug-seeking behavior after withdrawal from cocaine. The primary objectives are to: 1) monitor the activity of distinct interneuron subtypes in the infralimbic cortex during cocaine self-administration, 2) directly...
This $562,014 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) is funding research on the role of the medial habenula (MHB) and interpeduncular nucleus (IPN) circuits in opioid dependence and withdrawal. The research team at the University of California, San Diego (UCSD) is using molecular, physiological, and behavioral approaches to study how mu-opioid receptor (MOR) signaling in excitatory neurons in...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $772,800.00 to the University of Florida to conduct research aimed at identifying and pharmacologically targeting novel modulators of the mu-opioid receptor (MOR) signaling pathway. The overarching goal is to dissociate the beneficial analgesic effects of opioids from their harmful addictive properties by developing precision pharmacological...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), totaling $945,966 over the period of September 30, 2024 to July 31, 2029, will support research to unravel the neurobiological mechanisms by which the neuropeptide PEN and its receptor GPR83 interact with the mu-opioid receptor (MOR) in the periaqueductal gray (PAG) region of the brain. The goal is to determine if targeting the PEN-GPR83 pathway...
This $751,043 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research investigating the cellular and molecular mechanisms underlying the complex co-occurrence of opioid use disorder (OUD), major depressive disorder (MDD), and HIV in the human brain. The award will fund a comprehensive study using advanced multi-omics approaches, including single-nucleus RNA sequencing and single-nucleus ATAC...
This $373,300 Project Grant award from the National Institute on Drug Abuse (NIDA), under the federal Drug Use and Addiction Research Programs (CFDA 93.279), will support research to investigate the role of the nucleus accumbens (NAc) in learning and responding to reward-predictive cues. The research aims to enhance understanding of the neural activity dynamics in NAc that contribute to selective conditioned responses to reward-paired cues versus neutral cues. Using an auditory Pavlovian...