Project Grant R01DA063805
- This federal Project Grant award of $767,506 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) aims to leverage integrative modeling and AI-based tools to develop safer opioid painkillers. The project focuses on understanding how low-efficacy opioid receptor (MOR) agonists activate MOR-mediated G protein pathways differently from high-efficacy opioid drugs, in order to inform the design of safer opioid therapeutics. The award...
- This federal Project Grant award of $180,606.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will fund research at the Icahn School of Medicine at Mount Sinai to investigate the interplay between drug-induced long-term synaptic proteomic adaptations and the underlying transcriptional responses that drive these adaptations in a cell-type and circuit-specific manner within the brain's reward regions. The research aims to...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will fund research to investigate the role of cholinergic interneurons in the ventral tegmental area on opioid-related behaviors. The $373,181 grant, awarded on July 15, 2024 with a completion date of June 30, 2027, aims to determine whether mu-opioid receptors on cholinergic interneurons contribute to opioid reward, consumption, and withdrawal, and how...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the Drug Use and Addiction Research Programs (CFDA 93.279), provides $159,615.00 to the Icahn School of Medicine at Mount Sinai for a research project titled "Predicting Craving and Relapse Using Neurobehavioral Markers of Goals and Habits in Opioid Use Disorder". The primary objectives of the research are to track daily changes in motivational control during opioid addiction treatment, and use these...
- This $265,302 Project Grant awarded by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the neural mechanisms underlying opioid use disorder (OUD) and relapse risk during abstinence. The funded project will map the functional and anatomical pathways between the anterior and posterior paraventricular nucleus of the thalamus (PVT) and the nucleus accumbens (NAc), which have been implicated in the...
- The National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), awarded a $1,445,752 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to New York University School of Medicine. The grant, titled "Characterizing Complex OUD Care Trajectories and Outcomes Following Acute Service Utilization: A Population-Based Data Linkage Study," aims to apply novel research approaches to better understand real-world opioid use disorder (OUD)...
- The National Institute on Drug Abuse (NIDA) awarded a $569,743 Project Grant under the Drug Use and Addiction Research Programs (CFDA 93.279) to Yale University on July 15, 2025. The grant, titled "Y-SCORCH 2.0: Further Data Mining and Functional Characterization for Single Cell Opioid Responses in the Context of HIV (SCORCH) Program," aims to leverage advanced tools to analyze transcriptomic and epigenetic data from the SCORCH consortium and novel spatial transcriptomic data to...
- This $1,039,420 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to study the neuronal ensembles and circuits involved in the facilitation and disinhibition of opioid and alcohol seeking behaviors. The 5-year project, which begins on June 1, 2025 and runs through February 28, 2030, will employ innovative techniques such as single-nucleus RNA sequencing, spatial sequencing, and in vivo...
- This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $419,876 to conduct preclinical trials targeting the neuropeptide S (NPS) receptor to mitigate opioid taking and seeking behaviors in animal models. The goals of the project are to demonstrate proof-of-concept that NPS receptor-targeted molecules can reduce oxycodone self-administration and motivation in rats, which could inform the...
- This federal Project Grant award of $453,062.00 was provided by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health (NIH), under the Drug Use and Addiction Research Programs (CFDA 93.279). The award supports research to better understand the cellular mechanisms regulating opioid receptor signaling and the development of pharmacological tolerance, which is a critical challenge in the clinical management of opioid-based pain treatments. The research aims to...
This Project Grant award from the National Institute on Drug Abuse (NIDA), part of the Drug Use and Addiction Research Programs (CFDA 93.279), provides $787,594.00 to the Icahn School of Medicine at Mount Sinai to conduct research on the "Cortical Mechanisms of Opioid Reinforcement." The research aims to better understand the molecular, cellular, and circuit-based mechanisms underlying opioid use disorder (OUD). Specifically, the study will investigate the role of a specialized population of neurons in the dorsal peduncular nucleus of the ventral prefrontal cortex that express mu-opioid receptors and project to the parabrachial nucleus. The research will employ cutting-edge molecular, cellular, and behavioral approaches to elucidate how these neurons contribute to the motivational properties of opioids and the development of OUD. The award period runs from September 1, 2025 to May 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $787.6k | 8/22/25 |