Project Grant R00DA053633
- This federal Project Grant award of $390,687 was provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), to New York University (NYU) for a research project titled "CRCNS: MULTIREGIONAL COMPUTATIONS FOR VALUE-BASED DECISION-MAKING". The project aims to characterize how the orbitofrontal cortex (OFC), dorsal striatum (DSTR), and basolateral amygdala (BLA) brain regions interact to support belief updating and...
- This federal Project Grant award of $811,112 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research on the network and circuit dynamics underlying dopaminergic control of sudden insight learning. The principal investigator and research team at the University of California, San Francisco (UCSF) will use a combination of large-scale two-photon calcium imaging, high-density electrophysiology, dopamine sensor fiber...
- This federal Project Grant award of $476,496.00, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research at American University investigating the role of opioid signaling in reward-guided decision-making within the rat prefrontal cortex. The project, led by the Principal Investigator, will utilize intra-cortical pharmacology, computational modeling, and video analysis to examine how cortical opioid receptors...
- This federal Project Grant award for $330,027.00 from the National Institute on Drug Abuse (CFDA 93.279 - Drug Use and Addiction Research Programs) supports research to develop a computational-experimental framework for characterizing the complex dynamics of naturalistic social interaction across neural, behavioral, and social scales. The project will utilize simultaneously recorded behavioral and electrophysiology data from ferrets during natural social interactions to construct multiscale...
- This federal Project Grant award of $201,250 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research on the synaptic organization of cholinergic interneurons in the nucleus accumbens region of the brain. The study, conducted by New York University (NYU), aims to characterize the diverse excitatory and inhibitory inputs that contact these interneurons and influence their firing patterns. The research combines...
- This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support a comprehensive effort to analyze hundreds of multi-omic datasets related to the impact of substance use disorders (SUD) and HIV on the brain's reward circuitry and neuroinflammation. The $556,432 award, commencing on September 1, 2025, will enable researchers at the University of Maryland, Baltimore to: Assemble a harmonized resource of...
- This $403,542 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to profile projection-specific proteome associated with the incubation of oxycodone craving. The project will focus on the orbitofrontal cortex (OFC) to dorsal striatum (DS) projections, analyzing proteome changes in OFC neuronal somas (Aim 1) and OFC-DS projection-specific synaptoneurosomes in the DS (Aim 2) during the incubation of oxycodone...
- This $1,039,420 Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), will support research to study the neuronal ensembles and circuits involved in the facilitation and disinhibition of opioid and alcohol seeking behaviors. The 5-year project, which begins on June 1, 2025 and runs through February 28, 2030, will employ innovative techniques such as single-nucleus RNA sequencing, spatial sequencing, and in vivo...
- This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), aims to develop methods for integrating large-scale electron microscopy (EM) brain imaging data with functional and behavioral recordings. The $1,100,864 project, spanning from September 30, 2024 to September 29, 2027, will focus on relating the structure and function of neural circuits in the Drosophila brain. The proposed research seeks to...
- This federal Project Grant award of $613,786.00 from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is supporting research to elucidate the molecular, cellular, and physiological consequences of D1 dopamine receptor (D1DR) signaling from both the plasma membrane and Golgi compartments in primary medium spiny neurons. The research aims to advance understanding of the role of compartmentalized D1DR signaling in the neurobiology...
This federal Project Grant award of $248,717 from the National Institute on Drug Abuse (NIDA), under CFDA program 93.279 - Drug Use and Addiction Research Programs, supports research to investigate the neural circuits and mechanisms underlying orbitofrontal cortex signaling during learning. The project aims to test the hypothesis that the formation of integrated representations in the orbitofrontal cortex depends on activity in chemosensory, motor, and limbic areas, and that orbitofrontal cortex ensembles evolve to integrate value-based information. The research will be conducted at the University of Maryland, College Park over a 3-year project period from August 1, 2025 to July 31, 2028. The findings could provide new insights into how the brain forms cognitive maps that integrate sensory, motor, and value-based information to guide survival behaviors.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $248.7k | 8/13/25 |