This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), funds research to determine whether the recruitment of an infralimbic (IL) prefrontal cortex driver circuit is a hallmark of heroin-induced pathology, whether this IL subcircuit engages a positive feedback loop via the orexin system to exacerbate heroin seeking, and whether simultaneously targeting both IL subcircuits can reverse this pathology. The...
This $215,613 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under CFDA program 93.279 - Drug Use and Addiction Research Programs aims to investigate the role of the Reelin protein in the cellular and behavioral response to drugs of abuse. The principal investigator at the University of Alabama at Birmingham will use a multi-disciplinary approach to examine how Reelin facilitates dopamine signaling and related neuronal adaptations that promote drug-seeking behavior....
This federal Project Grant award of $445,500.00 from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) will support research to identify and characterize conserved regulators of drug-induced plasticity in the nervous system of the nematode Caenorhabditis elegans. The researchers at the University of Alabama at Birmingham will generate comprehensive molecular, behavioral, and neuronal activity atlases in response to acute and chronic...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is funding a $149,284 research project to investigate the role of different neuron subpopulations in the prefrontal cortex in regulating drug-seeking behavior. The University of Washington is the prime recipient for this 2-year award, which began in September 2024. The study aims to use combinatorial viral approaches, fiber photometry, and...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $148,568.00 to investigate the mechanisms of dopamine transmission and its role in reward-related behaviors. The 2.5-year project, running from January 1, 2025 to July 31, 2027, will be conducted by the University of Colorado-Denver, a prominent research institution. The research aims to advance understanding of how dopamine signaling at...
This federal Project Grant award, provided by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279), supports research to understand the molecular mechanisms by which opioids alter glutamatergic signaling and wiring of the reward circuit in the brain. The $666,569 award, with a period of performance from August 1, 2024 to May 31, 2029, will be utilized by the University of Florida to investigate the role of the cell-adhesion molecule ELFN1...
This federal Project Grant award, totaling $373,300.00, was made by the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279). The grant aims to study the role of the nucleus accumbens core (NAc) in learning the association between environmental cues and rewards, which is critical for understanding substance use disorder. Specifically, the research will use optogenetic inhibition and two-photon imaging techniques in mice to investigate how...
This $373,181 federal Project Grant award from the National Institute on Drug Abuse (NIDA) under the Drug Use and Addiction Research Programs (CFDA 93.279) supports research to investigate the role of cholinergic interneurons in the ventral tegmental area in opioid reward, consumption, and withdrawal. The research aims to determine whether mu-opioid receptors on these interneurons contribute to opioid-related behaviors and regulate dopamine release. The grant will fund experiments using...
This Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), provides $121,364 to the University of California, Los Angeles (UCLA) to conduct research on the role of dopamine projections to the amygdala in goal-directed and habit learning. Specifically, the research aims to use optogenetic manipulation and fiber photometry dopamine monitoring to characterize the function of dopaminergic projections from the ventral...
This federal Project Grant award from the National Institute on Drug Abuse (NIDA), under the Drug Use and Addiction Research Programs (CFDA 93.279), is providing $232,128 to the Regents of the University of Minnesota to conduct research aimed at characterizing the dopaminergic and glutamatergic mechanisms within the basolateral amygdala (BLA) that influence dynamic drug-seeking behaviors and craving in addiction. The research will utilize advanced neuroscience tools to measure in vivo dopamine...