Project Grant R03AG102042
- This Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), will support research to investigate the immunological and physiological mechanisms by which exercise can mitigate age-related skeletal muscle decline. The $190,374 award, effective September 1, 2025 through May 31, 2028, will enable researchers at Yale University to: Examine how mechanical stress-mediated activation of muscle stromal cells influences the inflammatory,...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- This federal Project Grant award of $308,799.00 was provided by the Department of Health and Human Services (HHS) National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310). The award supports a research project titled "Multi Omics Mapping of Exercise-Induced Interorgan Communication" at The Leland Stanford Junior University (Stanford University) with a period of performance from June 10, 2025 to May 31, 2026. The research project aims to...
- This federal Project Grant award of $2,358,537.00 from the National Institute on Aging (CFDA 93.866 - Aging Research) supports a research project titled "Epigenetic Aging, Cognitive Function and Exercise in Older Adults" at the University of Pittsburgh. The project aims to investigate the impact of exercise on epigenetic aging and its relationship to cognitive function, brain health, and Alzheimer's disease biomarkers in non-cognitively impaired older adults. The award period runs from...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- This federal Project Grant award of $116,710 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to improve understanding of sex-specific determinants of muscle quality (MQ) in older adults. The primary goals are to explore sex differences in factors impacting MQ, such as muscle mass, adiposity, and neurological impairment, and to develop targeted interventions to enhance MQ. The award will provide the principal investigator, an accomplished sports scientist, with training...
- This $120,573 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research by Dr. Matthew D. Campbell at the University of Washington to investigate dysfunctional redox-sensitive signaling mechanisms in aged skeletal muscle that impact metabolic function following exercise. The research aims to: 1) establish how dysfunctional redox signaling alters substrate utilization after exercise, 2) determine the impact on beta-oxidation and TCA cycle...
- This Project Grant award of $349,728.00 from the National Heart Lung and Blood Institute (CFDA 93.837 - Cardiovascular Diseases Research) supports research to identify and understand the cardiometabolic adaptations in male and female mice in response to acute and chronic exercise. The key objectives of the 3-year project are to: 1) determine the time course of the metabolic response to acute exercise in male and female mice; 2) identify the adaptations in cardiac substrate utilization and...
- This federal Project Grant award of $152,237.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant supports research to investigate neuromuscular adaptation to exercise in the early stages of Alzheimer's disease (AD). The project aims to determine the neuromuscular adaptive response to endurance exercise training in AD mouse models before the onset of overt AD-like pathology. Key objectives include assessing mitochondrial...
- This Project Grant award from the National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), aims to identify multi-scale mechanisms contributing to age-related increases in the metabolic cost of walking and decreases in walking speed. The $3,224,215 award to Georgia Tech Research Corp, to be completed by July 31, 2029, will leverage a multi-scale, computational-experimental approach to probe the cellular-to-behavioral mechanisms linking the...
This Project Grant award of $110,726.00 from the Department of Health and Human Services National Institutes of Health (NIH) under the Trans-NIH Research Support program (CFDA 93.310) aims to utilize data from the Molecular Transducers of Physical Activity Consortium (MoTrPAC) to characterize the molecular aging of white adipose tissue and the potential impact of endurance exercise training, with a focus on sex-specific differences. The research project led by the Pacific Northwest National Laboratory (PNNL) at Battelle Memorial Institute will: 1) Define the molecular aging of subcutaneous white adipose tissue, including the impact of sex, in the sedentary state, and 2) Determine the effect of age and sex on the response of subcutaneous white adipose tissue to endurance exercise training. This research seeks to better understand the systemic molecular mechanisms underlying the health benefits of exercise, particularly in relation to sex and age-associated differences in cardiometabolic disease risk.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $110.7k | 9/22/25 |