Project Grant K01AG092901

Award Date 8/1/25
Completion Date 4/30/30
Dollars Obligated $117K
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Connecticut, USA
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This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) provides $1,127,548 to the University of Texas Medical Branch at Galveston to investigate the role of post-translational modifications of myosin and its chaperone UNC-45 in the development of sarcopenia, the age-related loss of muscle mass and function. The project aims to use a combination of in vitro biochemical and biophysical assays, as well as in vivo techniques in the C. elegans model organism,...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
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