Project Grant K02AG088474
Award Date
7/1/25
Completion Date
3/31/29
Dollars Obligated
$152K
Federal Agency
National Institute on Aging
Federal Grant Program
93.866
Assistance Type
Project Grant
Place of Performance
Virginia, USA
Similar Awards
This federal Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to understand the mechanisms responsible for autophagy defects in neurons affected by Alzheimer's disease (AD). The $749,030 grant, awarded on December 15, 2024, will support experiments with a transgenic AD mouse model to evaluate the effects of various pharmacological interventions targeting calcium signaling and autophagy. The goal is to validate novel...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) provides $784,596 to Northeastern University to conduct comprehensive and cell type-specific proteogenomic profiling of aberrant and mis-processed proteins in Alzheimer's disease (AD) and tauopathy models. The research aims to expand understanding of protein dysfunctions in AD by profiling multiple brain regions across a large AD patient cohort and tauopathy mouse models, as well as conducting...
This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund a pilot study to evaluate the feasibility of using non-invasive neuroimaging techniques to monitor the metabolic and vascular functions of the brain and heart in a mouse model of Alzheimer's disease (AD). The $332,096 award, with a performance period from July 2024 to June 2026, will be made to The General Hospital Corporation (doing business as Massachusetts General Hospital). The research...
This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
This Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), aims to investigate the mechanisms underlying neuronal hyperexcitability in the entorhinal cortex (EC) of Alzheimer's disease (AD) mouse models. The $1,758,779 award, effective August 1, 2024 through July 31, 2026, will support studies to determine whether hyperexcitability is due to dysfunction of excitatory or inhibitory neurons in the EC. The research will use...
This $6,226,692 Project Grant awarded by the National Institute on Aging (NIA) under the Aging Research (CFDA 93.866) program supports research examining the role of neuronal hyperexcitability and proteostasis in the progression of Alzheimer's disease (AD). The study aims to use a mouse model to investigate how modifications in brain activity, specifically in the locus coeruleus (LC) and hippocampus (HPC), can lead to the pathological hallmarks of AD. Key objectives include tracking early...
The National Institute on Aging (NIA), under the Aging Research federal grant program (CFDA 93.866), awarded a $3,161,352 project grant (R01AG089069) to the University of Colorado-Denver. The 5-year grant, beginning on August 15, 2024, will fund a randomized controlled trial to investigate the molecular mechanisms underlying the heterogeneous effects of aerobic exercise training on peripheral and cerebrovascular function in adults of different ages and sexes. Key research activities include...
This $310,000 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research by Texas Tech University Health Sciences Center (TTUHSC) to examine how alternative polyadenylation (APA) of mRNAs contributes to the development and progression of Alzheimer's disease (AD). The project has two main goals: 1) to identify APA genes and pathways associated with AD pathology using computational analysis of existing single-cell RNA-sequencing datasets, and 2)...
This federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support research at Virginia Commonwealth University (VCU) to investigate the effect of the trans-synaptic spread of pathogenic tau protein in the hippocampus and its impact on vulnerable neuron subtypes in Alzheimer's disease (AD). The $408,638 award, effective from August 1, 2024 to July 31, 2026, will involve the use of adeno-associated viral vector transfection, immunofluorescence, and...
This federal Project Grant award of $189,199 from the National Institute on Aging (NIA), under its Aging Research program (CFDA 93.866), aims to study the relationships between cognition, physical activity, cardiorespiratory fitness, genetics, and the development of Alzheimer's disease (AD)-vulnerable brain networks in a cohort of periadolescent children (aged 8-13 years old). The award supports a cross-sectional study investigating how modifiable risk factors, such as physical activity and...