Project Grant K01AG086542
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington provides $485,375 to investigate the mechanisms underlying reduced resilience and adaptability of aging skeletal muscle. The project aims to determine whether increased mitochondrial redox stress drives the impairment of redox stress response signaling and declining muscle function with age. The researchers will use skeletal muscle contraction as a model to examine the...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- This $1,031,595 project grant from the National Institute on Aging, part of the Department of Health and Human Services, supports research under the Aging Research program (CFDA 93.866). The awardee, Dana-Farber Cancer Institute, will define the landscape and mechanisms of protein redox regulation during aging. Specifically, the Institute will systematically map cysteine oxidation networks in mouse tissues to determine their role in coordinating protein complex assemblies relevant to age-related...
- This Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), will support research to investigate the immunological and physiological mechanisms by which exercise can mitigate age-related skeletal muscle decline. The $190,374 award, effective September 1, 2025 through May 31, 2028, will enable researchers at Yale University to: Examine how mechanical stress-mediated activation of muscle stromal cells influences the inflammatory,...
- The National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), awarded a $216,460 project grant to The Research Foundation For The State University Of New York, operating as Upstate Medical Center. The grant will support research to investigate the mechanism by which mitochondrial protein import stress can induce myokine signaling, and how this signaling may mediate fat loss and improve cardiac health during aging. The project aims to advance scientific...
- The University of Southern California received a $126,042 project grant from the National Institute on Aging (NIA), under the Aging Research Federal Grant Program (CFDA 93.866), to investigate the role of mitochondrial proline catabolism, specifically the ALH-6 gene, in muscle-mitochondrial dynamics and their impact on health and longevity. This research builds upon previous studies in C. elegans that have linked ALH-6 mutations to premature aging, impaired muscle function, and mitochondrial...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
- This $530,469 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to Rowan University aims to investigate the role of the protein orosomucoid1 in mitigating age-related muscle loss and dysfunction (sarcopenia). The central hypothesis is that enhancing autophagy (a cellular process) through administering TAT-BECLIN1 and combining it with exercise will boost orosomucoid1 levels and improve muscle function in aged mice. The project seeks to determine if...
- This $454,938 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to define the impact of exercise on the aging nervous system. The project, led by Rutgers, The State University, will leverage the C. elegans worm model to characterize how regular exercise protects the nervous system against age-related dysfunction, including neuronal hyperactivity similar to brain aging in mammals. The research aims to elucidate the molecular...
This $120,573 federal Project Grant award from the National Institute on Aging (CFDA 93.866 Aging Research) supports research by Dr. Matthew D. Campbell at the University of Washington to investigate dysfunctional redox-sensitive signaling mechanisms in aged skeletal muscle that impact metabolic function following exercise. The research aims to: 1) establish how dysfunctional redox signaling alters substrate utilization after exercise, 2) determine the impact on beta-oxidation and TCA cycle flux, and 3) examine changes in mitochondrial protein interactions. The award will enable Dr. Campbell to expand his expertise in muscle and mitochondrial function by developing novel cell lines, conducting in vivo tissue metabolism assays, and analyzing large metabolomics and protein interaction datasets. The overarching goal is to advance understanding of the mechanisms linking age-related changes in redox signaling, metabolic deficits, and skeletal muscle function, with potential to inform interventions for improving muscle health in older adults.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $120.6k | 8/26/25 |