Project Grant K22AG088169
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will support the development and evaluation of a 3D engineered muscle tissue model to study the metabolic response to muscle contraction in the context of aging. The University of Washington, a prominent research institution, will lead this 2-year project to: 1) examine the mitochondrial mechanisms underlying the decreased metabolic response to muscle contraction in aged human 3D engineered...
- This Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) to the University of Washington provides $485,375 to investigate the mechanisms underlying reduced resilience and adaptability of aging skeletal muscle. The project aims to determine whether increased mitochondrial redox stress drives the impairment of redox stress response signaling and declining muscle function with age. The researchers will use skeletal muscle contraction as a model to examine the...
- This $485,375 Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) will fund research at the University of Washington to investigate genomic alterations in skeletal muscle associated with aging. The key objectives are to: Explore if alternative splicing of mRNA results in quantitative differential isoform changes associated with aging, potentially leading to increased expression of non-functional proteins relevant for healthy muscle function. The researchers...
- This federal Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) provides $170,900.00 to Rowan University to conduct research aimed at optimizing autophagy to counteract aging-induced muscle deterioration in mice. The central hypothesis is that combining the autophagy agonist TAT-Beclin1 with endurance exercise may enhance the benefits of exercise in halting the progression of sarcopenia, or...
- This Project Grant from the National Institutes of Health's National Institute on Aging, under the Aging Research program (CFDA 93.866), provides $287,218.16 in funding to the University of Maryland, Baltimore from August 1, 2021 through March 27, 2022. The award supports research aimed at better understanding the impact of aging on muscle excitability and action potential conduction velocity. Specifically, the recipient will use electrophysiology techniques and optical imaging to examine...
- This $454,938 federal Project Grant award from the National Institute on Aging (CFDA 93.866 - Aging Research) supports research to define the impact of exercise on the aging nervous system. The project, led by Rutgers, The State University, will leverage the C. elegans worm model to characterize how regular exercise protects the nervous system against age-related dysfunction, including neuronal hyperactivity similar to brain aging in mammals. The research aims to elucidate the molecular...
- This federal Project Grant award of $152,237.00 was provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866). The grant supports research to investigate neuromuscular adaptation to exercise in the early stages of Alzheimer's disease (AD). The project aims to determine the neuromuscular adaptive response to endurance exercise training in AD mouse models before the onset of overt AD-like pathology. Key objectives include assessing mitochondrial...
- This federal Project Grant award of $116,710 from the National Institute on Aging (CFDA 93.866 Aging Research) aims to improve understanding of sex-specific determinants of muscle quality (MQ) in older adults. The primary goals are to explore sex differences in factors impacting MQ, such as muscle mass, adiposity, and neurological impairment, and to develop targeted interventions to enhance MQ. The award will provide the principal investigator, an accomplished sports scientist, with training...
- The National Institute on Aging (NIA) awarded a $354,000 Project Grant under the Aging Research program (CFDA 93.866) to Panorama Research Incorporated, a for-profit biotech company in Sunnyvale, CA. The grant supports research to develop a novel therapy for sarcopenia, characterized by age-related loss of skeletal muscle mass, quality, and strength. The proposed therapy is based on the adipokine Isthmin 1 (ISM1), which has been shown to promote protein synthesis and suppress degradation...
- The University of Arkansas, Fayetteville was awarded a $141,890 project grant from the National Institute on Aging (CFDA 93.866 Aging Research) effective June 1, 2025, with a final completion date of July 31, 2030. The funded project, titled "Mediators of Muscle Rejuvenation with Aging", will examine the role of the MYC gene in skeletal muscle function, metabolism, cellular, and molecular changes throughout the lifespan, including how MYC induction may mimic the effects of exercise and...
This Project Grant award, provided by the National Institute on Aging (NIA) under the Aging Research program (CFDA 93.866), will support research to investigate the immunological and physiological mechanisms by which exercise can mitigate age-related skeletal muscle decline. The $190,374 award, effective September 1, 2025 through May 31, 2028, will enable researchers at Yale University to: Examine how mechanical stress-mediated activation of muscle stromal cells influences the inflammatory, metabolic, and functional adaptations to exercise in young and aged mice. Determine the contributions of muscle stromal cells and macrophages to the opposing effects of inflammation and exercise training on age-related decline in muscle function. The research aims to advance the scientific understanding of how exercise-induced immunomodulation can impact muscle physiology and counteract age-related muscular decline, with the goal of informing the development of exercise-based interventions to enhance healthy aging.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $190.4k | 8/26/25 |