Project Grant R01HD120349
- The National Institute of Child Health and Human Development awarded Oregon Health & Science University $752,721 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct research on the impact of semaglutide on maternal-fetal health outcomes. The research uses a non-human primate model of maternal obesity to evaluate whether preconception weight loss achieved through semaglutide treatment, continued through pregnancy and weaning,...
- The National Institute of Child Health and Human Development awarded Massachusetts General Hospital $672,715 on June 18, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct the Metabolic Assessment of Metformin in Pregnancy (MOM-P) study. The award funds research to assess the physiological effects of metformin on maternal and neonatal metabolism during pregnancy in individuals developing gestational diabetes mellitus. The study examines...
- The National Institute of Child Health and Human Development awarded Weill Medical College of Cornell University $727,070 on June 2, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to derive real-world insights from electronic health records and machine learning to inform clinical trials for pregnant individuals taking medications. The project addresses critical evidence gaps arising from the routine exclusion of pregnant women from clinical trials....
- The National Institute of Child Health and Human Development awarded Vanderbilt University Medical Center $481,250 on September 1, 2026, under the Child Health and Human Development Extramural Research Projects program (CFDA 93.865, R21HD120973) to investigate associations between adverse pregnancy outcomes, severe maternal morbidity, maternal mortality, and cardiovascular events across women's complete reproductive histories. The recipient will assemble retrospective cohort studies combining...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University Medical Center $449,242 on May 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847, Project Grant R01DK144134) to investigate how maternal diet and metformin use during pregnancy affect offspring pancreatic islet beta cell development and function. The research uses a rhesus macaque model to determine whether metformin exposure, alone or combined...
- The National Institute of Child Health and Human Development awarded Baylor College of Medicine $695,659 on May 15, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to explore adrenomedullin's actions in gestational diabetes mellitus using mouse models. The research investigates the causal role of adrenomedullin (ADM), a multifunctional peptide, in the development of gestational diabetes mellitus, which affects up to 18% of pregnancies in the U.S....
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded The General Hospital Corporation, doing business as Massachusetts General Hospital, $835,245 on September 1, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award funds research to evaluate evidence-based strategies for preventing weight regain after discontinuation of high-dose glucagon-like peptide-1 (GLP-1) agonist therapy in adults with obesity history but...
- The National Institute of Child Health and Human Development awarded Trustees of Tufts College (Tufts University School of Medicine) $740,405 on September 1, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a randomized controlled trial testing medically tailored groceries as an intervention to improve pregnancy outcomes among food-insecure pregnant women. The trial will enroll 458 pregnant women with food insecurity, randomizing...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Vanderbilt University Medical Center $354,714 on September 9, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct a pilot Phase II open-label clinical trial investigating adjuvant tirzepatide (TRZ) therapy in post-bariatric surgery patients. The research addresses a critical gap in obesity treatment. While gastric bypass surgery remains the most effective obesity...
- The National Institute of Diabetes and Digestive and Kidney Diseases awarded Children's Hospital Los Angeles $884,146 on June 5, 2026, to conduct a randomized clinical trial examining early re-initiation of semaglutide after metabolic and bariatric surgery in obese youth. The trial will enroll 80 youth ages 12–18 years with class III obesity who received semaglutide preoperatively and underwent metabolic and bariatric surgery. Participants will be randomly assigned to either early reintroduction...
The National Institute of Child Health and Human Development awarded Vanderbilt University Medical Center $785,385 on September 2, 2026, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to evaluate the safety and efficacy of glucagon-like peptide-1 receptor agonists (semaglutide, liraglutide, tirzepatide) for pre-pregnancy weight management and pregnancy outcomes. The research leverages the National Patient Centered Clinical Research Network to conduct a retrospective electronic health record-based cohort analysis of women with pregnancies and their infants. The study addresses knowledge gaps regarding GLP-1RA use prior to or during pregnancy, hypothesizing that pre-pregnancy GLP-1RA use reduces obesity-related pregnancy complications including gestational diabetes and hypertensive disorders. The analysis also examines whether GLP-1RA discontinuation prior to or early in pregnancy correlates with increased gestational weight gain relative to other anti-obesity medications. Work is performed in Forest Hills, Tennessee, with a period of performance from September 2, 2026, through June 30, 2031. This is a Project Grant assistance type.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $785.4k | 9/2/26 |