Project Grant K23DK143312
- This Project Grant award of $325,408 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) supports the development of an easy-to-operate endoscopic automatic gastroplasty device that mimics the effect of gastric bypass/bariatric surgery. The device is intended to provide a minimally invasive, non-surgical weight loss solution for the treatment of diabetes and obesity. The technology creates a reinforced circular plication of stomach tissue to reduce the stomach...
- This Project Grant award of $3,103,125 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to understand the role of lipogenic pathways in intestinal remodeling after Roux-en-Y gastric bypass surgery. The central hypothesis is that alterations in intestinal epithelial lipid homeostasis, driven by LXR and PPARA signaling, are necessary for Roux limb...
- This federal Project Grant award of $828,771 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research to study the neural mechanisms underlying the metabolic benefits of bariatric surgeries, such as vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB). The key objectives are to employ electrophysiological techniques to analyze changes in neuronal excitability and...
- This Project Grant award of $2,608,068.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is funding research to study the impact of bariatric surgery on skeletal health. The primary objectives are to investigate how changes in gastric secretory factors, such as ghrelin and somatostatin, contribute to bone loss following vertical sleeve gastrectomy (VSG) surgery. The...
- The University of Texas Health Science Center at San Antonio received a $775,865 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) on September 10, 2025. The award supports research to investigate the glycemic effects of glucagon in individuals with and without gastric bypass or sleeve gastrectomy surgery. The research aims to measure the impact of exogenous glucagon...
- This $315,342 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Velum Inc., a pharmaceutical research company based in Cambridge, Massachusetts. The grant supports the development of a novel weight loss drug centered on the peptide hormone Peptide YY (PYY). The goal is to create a chimeric triagonist molecule that combines the effects of PYY...
- This $942,000 federal project grant was awarded on September 16, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports a feasibility project at Rush University Medical Center to develop a primary care-based weight management treatment program for individuals discontinuing anti-obesity medications (AOMs). The goal is to quickly identify patients who...
- This $2,559,138 Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to define the mechanisms regulating adipose (fat) tissue metabolic memory and its role in rebound weight gain following obesity treatment. The project, led by researchers at the University of Pennsylvania, aims to: 1) determine the role of LYVE1+ macrophages in...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $322,800 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Mayo Clinic in Minnesota. This randomized, placebo-controlled trial will examine the effects of long-acting GLP-1 or dual incretin (GLP-1 and GIP) modulation on gastrointestinal functions and their relationship to weight loss. The research aims to investigate the heterogeneous effects of...
- This $802,363 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund a research study at Emory University from September 2025 to June 2030 to develop models for predicting the benefits of GLP-1 receptor agonist (GLP-1RA) treatments in preventing obesity-related cardiometabolic diseases. The study aims to use clinical...
This $177,986 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847) to Vanderbilt University Medical Center supports a pilot, phase II, open-label clinical trial. The study aims to determine the impact of administering the adjuvant weight loss medication tirzepatide (TRZ) on weight, fat mass, and lean body mass in patients with a history of gastric bypass surgery. The 5-year project, beginning September 9, 2025 and ending July 31, 2030, will enroll patients 12 months post-gastric bypass with a BMI of at least 30 kg/m2. The study seeks to investigate whether gastric bypass surgery might mitigate the gastrointestinal side effects commonly associated with TRZ, while allowing for enhanced weight loss with its use in the post-operative period.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $178.0k | 9/9/25 |