Project Grant R01HD120371
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Alabama at Birmingham a $1.93 million Project Grant on March 4, 2026, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct a 10-year follow-up study of children exposed to metformin in utero during the Medical Optimization and Management of Pregnancies with Overt Type 2 Diabetes (MOMPOD) trial. The study will...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded a $695,659 Project Grant to Baylor College of Medicine, effective May 15, 2026 through February 28, 2031, under the Child Health and Human Development Extramural Research program (CFDA 93.865). This research initiative will investigate adrenomedullin's (ADM) role in gestational diabetes mellitus (GDM) using innovative mouse models and genetic approaches. The research addresses a significant...
- Federal Project Grant Award Summary Vanderbilt University Medical Center received a $449,242 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective May 1, 2026 through April 30, 2028. The award supports biomedical research investigating the effects of maternal metformin exposure and Western-style diet consumption on fetal pancreatic islet beta cell...
- Federal Project Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded Massachusetts General Hospital $170,640 on August 1, 2025, under the Child Health and Human Development Extramural Research program (CFDA 93.865) to support a five-year research project examining the role of the fibroblast growth factor receptor 1 (FGFR1) signaling pathway in the intersection of reproduction and metabolism. The research will elucidate how distinct fibroblast growth...
- Federal Project Grant Award Summary Harvard T.H. Chan School of Public Health received a Project Grant award of $238,168 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), with an award date of July 15, 2025, and completion date of September 18, 2025. The research project examines in utero exposure to cardiometabolic medications and the associated risk of congenital malformations. The...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded Massachusetts General Hospital $443,954 under the Child Health and Human Development Extramural Research program (CFDA 93.865) to conduct a four-year mixed-methods research project on obstetric readiness in emergency departments. The project, which commenced June 1, 2026 and concludes February 28, 2030, addresses critical gaps in maternal health outcomes by developing standardized...
- Federal Project Grant Award Summary Cincinnati Children's Hospital Medical Center received a $474,878 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), awarded August 1, 2025, with a completion date of July 31, 2027. The research project, "Quantifying the Impact of Hyperglycemia on Embryonic Metabolism and Development in C. elegans," generates single-cell...
- Federal Project Grant Award Summary The University of Pittsburgh received a $1,014,969 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025, through April 30, 2030. This award supports investigator-initiated research examining the mechanistic role of insulin receptor substrate 1 (IRS1) in beta-cell compensation during pregnancy and the etiology of...
- Federal Grant Award Summary The National Institute of Child Health and Human Development (NICHD) awarded Metis Foundation a Project Grant of $323,470 under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective July 1, 2025, through June 30, 2030. This award funds a pilot feasibility study and associated research training for a virtual single-session cognitive-behavioral therapy (CBT)-informed intervention targeting loss-of-control (LOC) eating during...
- Federal Grant Award Summary Oregon Health & Science University received a $1,512,345 Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective August 1, 2025, through April 30, 2030. The research investigates placental essential fatty acid (EFA) metabolism in gestational diabetes mellitus (GDM) using integrative spatial multiomics approaches. The project...
The Metabolic Assessment of Metformin in Pregnancy (MOM-P) study, funded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), is a clinical research project awarded to Massachusetts General Hospital (MGH) in the amount of $672,715. The award, dated June 18, 2026, with a completion date of March 31, 2031, will deliver comprehensive metabolic assessment services examining the physiological effects of metformin on maternal and neonatal metabolism in pregnancies complicated by gestational diabetes mellitus (GDM). MGH will conduct three integrated research aims across two sites—MGH in Boston and Ohio State University College of Medicine—recruiting 50 and 100 participants respectively from the DECIDE multicenter randomized controlled trial. The research will produce metabolic data quantifying metformin's effects on endogenous glucose production and insulin sensitivity through stable isotope glucose infusion studies, characterize associations between metformin use and growth differentiation factor 15 (GDF15) levels with maternal weight gain and energy expenditure, and evaluate neonatal metabolic outcomes. These clinical research activities will advance understanding of metformin's role in GDM management and address current inconsistencies among major medical organizations regarding its appropriate use in pregnancy.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $672.7k | 6/19/26 |