Project Grant R01HD113553

Award Date 9/1/24
Completion Date 5/31/29
Dollars Obligated $1.5M
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Minneapolis, MN 55455, USA
Similar Awards
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support the development of a microfluidic human placenta organoid model at Syracuse University. The $411,125 award will fund research to derive human trophoblast stem cells from induced pluripotent stem cells and use them to generate placental organoids that can recapitulate early-to-mid gestation...
The National Institute of Child Health and Human Development (NICHD) awarded a $1,454,109 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Colorado State University (CSU) to conduct research on the physiological and genetic basis of placental adaptations to hypoxia during pregnancy. The 5-year grant, starting on July 1, 2024, will investigate how individual placental cell type responses to hypoxia contribute to adverse fetal outcomes, such...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will fund research to identify the mechanism by which fetal glucagon regulates placental nutrient delivery. The $148,568 award to the University of Colorado-Denver aims to demonstrate that fetal glucagon acts by inhibiting placental trophoblast secretion of maternal placental lactogen (CSH), which in turn...
This $448,441 federal Project Grant awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research at Emory University to investigate the role of mediobasal hypothalamic gliosis in gestational weight gain and visceral fat accretion. The primary aim is to provide foundational data on a potential neural mechanism underlying dysregulated or pathological weight gain during...
The federal Project Grant award R21HD111905, with a total funding of $234,000.00, was provided by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The primary awardee, The Regents of the University of Colorado (University of Colorado-Denver), will conduct research to investigate the functional importance of a novel NF-kB genetic variant (rs230511) and its role in the development of...
The National Institute of Child Health and Human Development (NICHD) awarded a $1,576,519 Project Grant (CFDA 93.865 - Child Health and Human Development Extramural Research) to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) to study the role of the RNA methyltransferase METTL3 in mammalian placental development and maintenance. The research aims to investigate how METTL3 impacts trophoblast progenitor cell self-renewal, differentiation, and function in mouse models...
This $293,756 federal Project Grant (R21HD112819) was awarded on July 11, 2024 by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant supports research to enhance understanding of the molecular mechanisms underlying placental dysfunction in common obstetric disorders such as preeclampsia, preterm birth, and fetal growth restriction. The research, led by the Institute for Systems...
The National Institute of Child Health and Human Development (NICHD) awarded a $539,000 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Regents of the University of Minnesota, Office of Sponsored Projects Administration. This 5-year project, which commenced on August 22, 2024, aims to evaluate the population-level effectiveness and cost-effectiveness of interventions across the preconception to postpartum continuum to inform optimal...
This Project Grant award of $1,829,617 from the National Institute of Child Health and Human Development (NICHD) under CFDA 93.865 Child Health and Human Development Extramural Research, aims to develop stem cell-based models to study placental defects associated with early-onset preeclampsia. The 5-year project, commencing on July 1, 2024, will pursue three key objectives: 1) Identify optimal stem cell methods to model abnormal trophoblast differentiation in preeclampsia placentas, 2)...
This Project Grant award, totaling $152,816.00, was issued by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865). The award aims to investigate the link between Down's syndrome (trisomy 21) and placentation defects that contribute to adverse pregnancy outcomes and congenital heart disease. The research project has three key objectives: 1) Identify transcriptional differences in...

This $1,538,070 federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), supports research to investigate the mechanisms by which glucose and glutamine metabolism regulate trophoblast differentiation and placental development. The awardee, the Regents of the University of Minnesota, will use CRISPR-Cas9 genetic tools to manipulate the expression of the mitochondrial pyruvate carrier (MPC) and glutamine transporter (SLC1A5VAR) in human trophoblast stem cell models. They will measure cellular metabolism, epigenetic changes, and trophoblast differentiation to reveal nutrient-responsive mechanisms controlling placental development. The research aims to define fundamental pathways to fine-tune placental fuel use and improve pregnancy outcomes for women with obesity and diabetes. The project period runs from Sep 1, 2024 to May 31, 2029.

Generated 6/24/25, 6:15 AM