This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), will provide $156,500.00 to the University of Hawaii to create an in vitro model of the human yolk sac using human pluripotent stem cells. The objective is to establish an experimentally tractable model of the human yolk sac, a vital extra-embryonic organ for early embryo development, to study its...
The National Institute of Child Health and Human Development (NICHD), under the federal Child Health and Human Development Extramural Research program (CFDA 93.865), awarded a $1,829,617 Project Grant to the University of California, San Diego (UCSD) to conduct research on stem cell-based modeling of placental defects associated with early-onset preeclampsia. The 5-year project, running from July 1, 2024 to April 30, 2029, aims to identify optimal stem cell-based methods to study abnormal...
This Project Grant award of $1,454,109 from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) will support research to investigate the physiological and genetic basis of how the placenta responds to hypoxia (low oxygen) during pregnancy. The research aims to address three key questions: 1) how individual placental cell type responses to hypoxia contribute to overall tissue-level outcomes, 2)...
The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...
The National Institute of Child Health and Human Development (NICHD) awarded a $461,780 R21 project grant (CFDA 93.865: Child Health and Human Development Extramural Research) to The Regents of the University of California, San Francisco (UCSF) on August 1, 2023 to investigate the feasibility of a clinical-scale, anticoagulation-free artificial placenta device. The project aims to overcome key barriers to the clinical translation of artificial placenta technology, which is designed to simulate...
This Project Grant award from the National Institute of Environmental Health Sciences (NIEHS) under the Environmental Health (CFDA 93.113) program aims to establish an in vitro yolk sac organoid model using human pluripotent stem cells. The $156,500 award, effective September 13, 2024, with a completion date of August 31, 2026, will support the development and characterization of this yolk sac model, including examining the effects of high glucose levels to provide insights into diabetic...
This Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) supports a research project focused on investigating the regulation of trophoblast cell development, which is critical for successful pregnancy establishment. The $1,887,823 award to the University of Kansas Medical Center Research Institute, Inc. aims to elucidate the roles of the activin-follistatin like 3 and Wnt-Wnt antagonist...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $760,617 in funding to Boston Children's Hospital to conduct research on the mechanisms underlying pluripotency transitions during peri-implantation embryonic development. The research aims to identify key transcription factors and elucidate the epigenetic regulation involved in the transitions...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $309,251 to Expanse Bio LLC to develop an ex vivo microfluidic organ perfusion device for long-term culture and assessment of whole ovaries. The goal is to create a more physiologically relevant model for evaluating the ovotoxicity (ovarian damage) potential of drug candidates, particularly...
This federal Project Grant award, valued at $1,474,108, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The research aims to elucidate the cellular and molecular mechanisms underlying placenta accreta, a serious maternal condition characterized by excessive placental invasion into the uterus, which is often associated with previous uterine scarring. The research project will...