Project Grant R21HD111905
Award Date
8/1/24
Completion Date
7/31/26
Dollars Obligated
$234K
Federal Agency
National Institute of Child Health and Human Development
Federal Grant Program
93.865
Assistance Type
Project Grant
Place of Performance
Aurora, CO 80045, USA
Similar Awards
This federal Project Grant award, totaling $456,251.00, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The overarching goal of the proposed research is to test the hypothesis that pro-inflammatory mediators produced by maternal adipose tissue (leptin) reduce pro-angiogenic immune cells and factors at the maternal-fetal interface, which can contribute to adverse pregnancy outcomes...
This $148,880 Project Grant, awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), will support research on the long-term effects of preeclampsia (PE) on maternal and offspring health. The primary objectives are to: Determine if B cells from PE women produce autoantibodies (AT1-AA) that contribute to hypertension, cerebrovascular dysfunction, and cognitive impairment in the mother...
This $250,000 Project Grant award from the National Heart, Lung, and Blood Institute (NHLBI) under the Cardiovascular Diseases Research program (CFDA 93.837) will support research at Colorado State University to investigate the role of maternal gut microbiome and inflammation in preeclampsia and subsequent cardiometabolic disease in offspring. The key research aims are to: 1) Determine if the maternal gut microbiome contributes to pro- or anti-inflammatory short-chain fatty acid signaling at the...
The University of Texas at Austin received a $191,965 Project Grant (R21HD115116) from the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The grant is funding a 2-year research project to identify and functionally validate key transcription factors that control preeclampsia-specific gene expression programs, and to understand the regulatory mechanisms of these preeclampsia-driving transcription...
This federal Project Grant award, valued at $1,888,904.00 and awarded by the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), aims to reduce the risk of chronic hypertension and improve vascular function following preeclampsia. The research focuses on the mechanisms behind the increased risk of cardiovascular disease in patients who have experienced hypertensive disorders of pregnancy,...
This $232,500 Project Grant awarded by the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) to Wake Forest University Health Sciences will fund research to establish the neuroprotective actions of the apelinergic axis on the long-term cerebrovascular consequences of preeclampsia. The research aims to improve understanding of the protective role of the apelin/APJ axis in preeclampsia, a hypertensive disorder of...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under CFDA Program 93.865 (Child Health and Human Development Extramural Research), provides $250,500.00 to Cedars-Sinai Medical Center to conduct research on the role of the metabolite L-kynurenine in the pathogenesis of preeclampsia in mouse models with impaired renal reserve. The research aims to understand the mechanisms by which deficiency of L-kynurenine during pregnancy...
The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), is supporting research to develop a targeted, placenta-tropic lipid nanoparticle (LNP) platform for the delivery of mRNA therapeutics to treat pre-eclampsia, a serious pregnancy complication. The $349,375 award will fund the evaluation of a large library of novel ionizable LNPs for placental tropism,...
This federal Project Grant award from the National Institute of Child Health and Human Development, under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $148,568 to the University of Colorado-Denver to investigate the mechanism by which fetal glucagon regulates placental nutrient delivery. The goal is to identify how fetal glucagon acts to match placental nutrient supply to fetal metabolic demand, particularly in pregnancy complications involving...