This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $130,680 to the University of Kansas Medical Center Research Institute, Inc. (KUMCRI) for a project titled "Early Events in Extravillous Trophoblast Cell Differentiation." The research aims to investigate the role of the transcription factor CCAAT/enhancer-binding protein beta (CEBPB)...
The National Institute of Child Health and Human Development (NICHD) has awarded a $423,985 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the University of Illinois to develop a novel non-invasive monitoring system for detecting placental dysfunction and associated pregnancy complications. The funding will support research to utilize extracellular vesicles (EVs) circulating in maternal blood as biomarkers, using a "target recycling...
This federal Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) is focused on developing epigenomic liquid biopsy methods for early detection and prediction of preterm birth, preeclampsia, and intrauterine growth restriction. The total grant award of $717,871 to the Magee-Womens Research Institute and Foundation aims to create non-invasive screening tools to...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under the Child Health and Human Development Extramural Research program (CFDA 93.865), provides $1,538,070 to the Regents of the University of Minnesota to study the role of mitochondrial nutrient transport in regulating trophoblast differentiation. The research aims to reveal novel, nutrient-responsive mechanisms controlling epigenetic and transcriptional reprogramming events foundational to...
This Project Grant award, valued at $232,500.00, was provided by the National Institute of Child Health and Human Development under the Child Health and Human Development Extramural Research program (CFDA 93.865). The funding supports research to investigate the role of circular RNA (circRNA) in ovarian follicular development and fertility. The project will examine the effect of the KHDRBS1 protein on circRNA biogenesis and its impact on fertility using a granulosa cell-specific KHDRBS1 knockout...
This $3,422,481 Project Grant award from the National Institute of Child Health and Human Development (CFDA 93.865 - Child Health and Human Development Extramural Research) will support a comprehensive genomic research program at Children's Mercy Hospital to characterize novel causes of unexplained recurrent pregnancy loss (RPL). The program will leverage the hospital's large clinical RPL service and existing Genomic Answers for Kids (GA4K) pediatric rare disease database to procure carefully...
The National Institute of Child Health and Human Development (NICHD) awarded a $986,581 Project Grant under the Child Health and Human Development Extramural Research program (CFDA 93.865) to Texas A&M Agrilife Research. The award, which runs from August 2024 to May 2029, will fund research to investigate how alterations to the paternal epigenome, specifically the histone components of sperm chromatin, may contribute to pregnancy loss and impaired embryo development in cattle and humans. The...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD), under CFDA program 93.865 Child Health and Human Development Extramural Research, will support research to investigate the role of histone demethylase enzymes KDM3A and KDM3B in the development of primordial germ cells during mouse embryonic development. The $160,877 award to the University of Wisconsin-Madison will fund experiments using an in vitro model of primordial germ cell differentiation...
This Project Grant award, valued at $293,756, was provided by the National Institutes of Health (NIH) under the Child Health and Human Development Extramural Research program (CFDA 93.865) to the Institute for Systems Biology (ISB). The funding will support research to enhance understanding of placental dysfunction in common obstetric disorders like preeclampsia, preterm birth, and fetal growth restriction. The research aims to identify molecular mechanisms and network-level patterns...
This Project Grant award from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) provides $1,963,122 to the University of Missouri System to conduct research on the molecular mechanisms regulating uterine development. The research aims to define critical physiological and genetic pathways that regulate uterine development, function, and regeneration in order to diagnose, treat, and prevent...