Project Grant R01EY039110
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $693,423 to the University of Mississippi Medical Center on September 15, 2025, under the Vision Research program (CFDA 93.867) to develop and test a multivalent antibody cocktail for treating and preventing bacterial endophthalmitis. The funded research combines eight antibodies targeting virulence factors of Staphylococcus epidermidis, Staphylococcus aureus, and...
- The National Eye Institute awarded New York University $546,439 on April 15, 2026, under the Vision Research program (CFDA 93.867) to develop corneal stromal keratocyte modeling from human cornea organoids as a potential therapy for corneal blindness caused by stromal scarring, infection, and keratoconus. The research focuses on generating human cornea organoids from induced pluripotent stem cells that mimic the fetal cornea and co-differentiate stromal keratocytes, epithelial, and endothelial...
- The National Eye Institute awarded the University of Rochester $678,201 on May 1, 2026, to develop a novel antimicrobial drug combination for treating bacterial keratitis under the Vision Research program (CFDA 93.867). This is a Project Grant (R61EY036951) with performance through April 30, 2028. The funded work advances development of a topical ophthalmic antibiotic combination of polymyxin B/trimethoprim plus rifampin to address bacterial keratitis, an aggressive corneal infection responsible...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded the Board of Regents of the University of Nebraska (University of Nebraska Medical Center) $1,267,127 on August 1, 2026 for Project Grant R01EY038077, funded under the Vision Research program (CFDA 93.867). The award funds clinical and molecular biomarker surveillance of mpox-related ocular disease. The research characterizes the spectrum of ophthalmic manifestations of mpox...
- The National Eye Institute, a bureau of the Department of Health and Human Services National Institutes of Health, awarded $497,740 to the University of Illinois on April 1, 2026, under the Vision Research program (CFDA 93.867) to fund research into neuro-epithelial interactions in corneal disease and repair, with Principal Investigator Elmira Jalilian. The project investigates how corneal epithelial cells and trigeminal nerve fibers (the V1 ophthalmic branch) interact to maintain corneal...
- The National Eye Institute awarded the University of Cincinnati Sponsored Research Services $445,500 on June 1, 2026, under the Vision Research program (CFDA 93.867) to conduct fate mapping and functional analysis of COL8A2-positive cells in corneal endothelial development and disease. The recipient will generate a tamoxifen-inducible COL8A2P2A-CREERT2 mouse line to enable temporal and tissue-specific labeling and manipulation of COL8A2-positive cells. In Aim 1, the team will use lineage tracing...
- The National Eye Institute awarded The University of North Texas Health Science Center at Fort Worth $249,000 on April 15, 2026, under the Vision Research program (CFDA 93.867) to investigate mechanisms that inhibit cell death in human corneal stromal cells as a pathway toward non-surgical treatment of keratoconus. The research aims to identify small-molecule compounds that inhibit activated caspase-8 and heparan sulfate compounds that block interactions between tumor necrosis factor-alpha and...
- The National Eye Institute awarded $175,293 to the Regents of the University of California, doing business as University of California, Berkeley, on July 1, 2026, under the Vision Research program (CFDA 93.867) for a Project Grant titled "The Impact of TRPA1/TRPV1 Activity on the Ocular Mucinome" (K08EY039016). The funded research investigates how transient receptor potential (TRP) cation channels—specifically TRPV1 and TRPA1 on corneal sensory nerves—modulate mucin expression and...
- The National Eye Institute awarded the University of California Irvine $431,750 on May 1, 2026, under the Vision Research program (CFDA 93.867) to explore novel mechanisms of obstructive meibomian gland dysfunction. The research tests the hypothesis that alterations in meibum lipid synthesis cause obstructive meibomian gland dysfunction, leading to duct dilation and psoriasis-like epithelial inflammatory disease. The work involves confirming that human meibomian gland epithelial cell (HMGEC)...
- The National Eye Institute awarded the Board of Regents of the University of Nebraska, through its University of Nebraska Medical Center division, $383,750 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate oxidative stress and NLRP3 inflammasome activation in eye lens pathobiology during aging. The research examines molecular pathways linking reactive oxygen species amplification, dysregulation of antioxidant defenses, and inflammasome-driven inflammatory...
The National Eye Institute awarded the University of Mississippi Medical Center $584,806 on August 1, 2026, under the Vision Research program (CFDA 93.867) to investigate mechanisms of adhesion and colonization during pneumococcal keratitis caused by Streptococcus pneumoniae. The research examines how pneumococcal bacteria regulate their outer polysaccharide capsule to adhere and colonize the corneal surface, and identifies a master regulatory system that controls bacterial survival and virulence mechanisms including oxidative stress resistance, metal toxicity resistance, and biofilm formation. The study will characterize how capsule biosynthesis is modulated at the cornea and how the regulatory system promotes bacterial fitness in the ocular environment, with the goal of identifying factors controlling bacterial survival to drive development of novel therapies preserving corneal function. The award period runs through March 31, 2030, with place of performance in Jackson, Mississippi.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $584.8k | 7/27/26 |