Project Grant R00EY035260
- Federal Grant Award Summary The University of North Texas Health Science Center at Fort Worth received a $402,439 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) beginning April 1, 2026 and concluding March 31, 2029. This award funds the development and clinical evaluation of a novel personalized contact lens designed to enable collagen cross-linking (CXL) therapy for keratoconus patients with thin corneas. The research team will design and...
- Federal Grant Award Summary New York University School of Medicine received a $546,439 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with completion anticipated by March 31, 2030. The award funds research to develop corneal stromal keratocyte modeling from human cornea organoids (HCOs) as a potential therapy for corneal scarring and keratoconus-related blindness. The research leverages HCOs generated from induced...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant totaling $900,600 to The Regents of the University of California, San Francisco, with an award date of September 1, 2025, and completion date of August 31, 2027, under the Vision Research program (CFDA 93.867). This award funds research directed at understanding corneal limbal stem cells (LSCs) during wound healing processes. The project addresses the significant clinical need for restorative treatments for...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant totaling $540,213 under the Vision Research program (CFDA 93.867) to investigate the fibrosis-immunity interface in corneal transplantation. Beginning August 1, 2025, and extending through July 31, 2030, this research program will deliver scientific findings aimed at improving corneal transplant survival rates by elucidating the mechanisms by which myofibroblasts...
- Federal Grant Award Summary New York University School of Medicine received a $285,498 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective September 30, 2025, with an ultimate completion date of August 31, 2027. This research grant funds fundamental scientific investigation into corneal lens development mechanisms using Drosophila (fruit fly) as a model organism to better understand human corneal curvature disorders including...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant of $497,740 to the University of Illinois (Chicago, IL) under the Vision Research program (CFDA 93.867), effective April 1, 2026, through March 31, 2031. Under the direction of Principal Investigator Elmira Jalilian, this research project will generate scientific findings and empirical data examining neuro-epithelial interactions in corneal disease and repair, with particular focus on how corneal nerves...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $144,618 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025 through March 31, 2028. The grant funds research investigating fucosylation as a mediator of limbal stem cell (LSC) viability. The research focuses on understanding how fucose, a monosaccharide component of the cell surface glycocalyx, influences the survival of limbal stem...
- This $394,285 federal Project Grant was awarded on May 1, 2025 by the National Eye Institute (CFDA 93.867 Vision Research) to the University of Houston System to develop decorin-based therapeutics for treating corneal scarring and neovascularization. The research aims to characterize the binding interfaces of decorin with TGF-β1 and VEGFR2 in order to engineer novel decorin-based drugs to inhibit corneal fibrosis and angiogenesis following corneal injuries. This work aligns with the National Eye...
- Federal Grant Award Summary Wayne State University received a $1.19M Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective May 1, 2025 through February 28, 2029. The award funds research investigating a peptide-based combination therapy (TB4/VIP) designed to restore structure and function in diabetic corneas by targeting hyperglycemia-responsive cellular circuits. The research addresses a significant clinical gap, as current treatment...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded The Ohio State University $433,125 on August 1, 2025, to investigate tissue factor (TF) as a potential biomarker and therapeutic target for corneal neovascularization (CNV). This two-year project, concluding July 31, 2027, addresses a significant unmet medical need, as CNV—the pathological growth of blood vessels in the cornea—is a common sequela of corneal diseases...
The University of North Texas Health Science Center at Fort Worth received a $249,000 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with completion targeted for March 31, 2029. This research initiative focuses on identifying therapeutic interventions to prevent cell death in human corneal stromal cells as a non-surgical treatment approach for keratoconus, a progressive corneal disorder affecting approximately 1 in 500 to 2,000 Americans. The project will deliver scientific research products including: (1) identification of small molecule compounds that inhibit activated caspase-8 through unbiased proteomics approaches using mass spectrometry and antibody-based assays; (2) heparan sulfate compounds screened via glycan microarray technology to interrupt tumor necrosis factor-alpha and TNF receptor interactions; and (3) validation of apoptotic inhibition effects in three-dimensional keratoconus cell models using nuclear magnetic resonance spectroscopy to characterize protein-ligand interaction kinetics. This award supports the NEI's mission to drive innovative research preventing and treating vision diseases. The research directly addresses a critical gap in keratoconus treatment by targeting the underlying biological mechanisms of keratocyte apoptosis and stromal thinning, with potential to reduce the 10-20% of KC patients currently requiring corneal transplant surgeries through pharmaceutical intervention rather than surgical procedures.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $249.0k | 4/9/26 |