Project Grant R01EY038446
- Federal Grant Award Summary The University of California, San Francisco received a $900,600 Project Grant from the National Eye Institute under the Vision Research program (CFDA 93.867) effective September 1, 2025, through August 31, 2027. This award supports research to advance understanding of corneal limbal stem cells (LSCs) during wound healing, specifically investigating how injury impacts the limbal stem cell niche and the distinct roles of inner limbal stem cells (ILSCs) and outer...
- Federal Project Grant Award Summary New York University School of Medicine received a $546,439 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with an ultimate completion date of March 31, 2030. This award funds research to develop corneal stromal keratocyte modeling from human cornea organoids (HCOs) derived from induced pluripotent stem cells (iPSCs). The research aims to generate novel therapeutic cell sources and...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $437,250 to the University of California, San Diego to develop an integrated bioprinting and optogenetics platform for evaluating neural activity in stem cell-derived retinal disease models. The award, effective September 1, 2025, through August 31, 2027, supports research aimed at creating a "visual-circuit-on-a-chip" by integrating three-dimensional (3D)...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $431,750 Project Grant to the University of California, Irvine under the Vision Research program (CFDA 93.867) for the period May 1, 2026 through April 30, 2028. This award funds exploratory research investigating novel mechanisms underlying obstructive meibomian gland dysfunction (O-MGD), a condition characterized by altered meibum lipid synthesis that leads to duct dilation and dry eye disease. The research will produce...
- Federal Grant Award Summary The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded the University of California, Los Angeles (UCLA) a Project Grant of $722,904 beginning May 1, 2026, and extending through April 30, 2031. This award funds the "Researching OCT Biomarkers in Uveitis Clinical Trials (ROBUST)" initiative, which will conduct secondary analysis of optical coherence tomography (OCT) imaging and clinical data from four NEI-funded uveitis...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $864,040 to The Leland Stanford Junior University beginning July 1, 2025, through June 30, 2030, to develop and test an intraocular projector implant platform designed to restore vision in patients with severe corneal injuries. The research addresses a significant clinical gap, as severe corneal damage from infections, chemical burns, thermal burns, and traumatic...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded The Schepens Eye Research Institute Inc. a $1.79M Project Grant (awarded September 1, 2025; completion date August 31, 2027) to investigate non-invasive transpalpebral electrical stimulation (TPES) as a therapeutic intervention for diabetic keratopathy (DK). This research addresses a significant clinical need, as current treatment options are costly, uncomfortable, and difficult...
- Federal Grant Award Summary The National Eye Institute awarded a $733,137 Project Grant to the University of California, Los Angeles (UCLA) on September 15, 2025, under the Vision Research program (CFDA 93.867) to conduct research on genetic variation in age-related macular degeneration (AMD) progression and treatment response. The research integrates advanced optical coherence tomography (OCT) imaging with machine learning (ML) and artificial intelligence (AI) to understand how genetic...
- Federal Grant Award Summary The University of Houston System received a $863,500 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 30, 2025, with a completion date of July 31, 2027. The research project investigates the mechanisms of scarless corneal wound healing by comparing the regenerative capabilities of the African spiny mouse (Acomys cahirinus) to standard laboratory mice (Mus musculus) following alkali burn...
Funding Agency: National Eye Institute The University of California, Los Angeles will develop an engineered adhesive biomimetic hydrogel platform designed to deliver mesenchymal stem cells (MSCs) to corneal tissue for regeneration and repair. The primary research products include a photocurable adhesive composite hydrogel based on chemically modified gelatin and hyaluronic acid that encapsulates and releases MSCs in a sustained manner. The platform comprises two distinct hydrogel variants with tunable mechanical properties and degradation rates: a soft, controlled-degradable adhesive hydrogel functioning as a bandage for epithelial regeneration, and a strong, highly adhesive hydrogel serving as stromal replacement while delivering MSCs to promote stromal repair. This biomaterial approach addresses the critical gap in effective MSC delivery methods for corneal diseases, a significant public health challenge in the United States that frequently results in vision impairment and reduced quality of life. The research aims to overcome existing limitations in MSC therapy related to poor cell survival and rapid matrix degradation associated with current delivery methods such as surface injection, fibrin gel, and amniotic membrane sheets. By optimizing MSC dosage and timing while improving cell survival and integration into corneal tissue, this project seeks to advance translational and applied research outcomes that may enable new therapeutic interventions for corneal injury and disease.Federal Grant Award Summary
Program: Vision Research (CFDA 93.867)
Award Amount: $527,987
Award Period: May 1, 2026 – April 30, 2030
Awardee: University of California, Los Angeles
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $528.0k | 4/29/26 |