Project Grant R01EY037916
- Federal Grant Award Summary The National Eye Institute awarded a $733,137 Project Grant to the University of California, Los Angeles (UCLA) on September 15, 2025, under the Vision Research program (CFDA 93.867) to conduct research on genetic variation in age-related macular degeneration (AMD) progression and treatment response. The research integrates advanced optical coherence tomography (OCT) imaging with machine learning (ML) and artificial intelligence (AI) to understand how genetic...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded University of California, Irvine $179,964 under the Vision Research program (CFDA 93.867) on March 1, 2025, for a project grant extending through July 10, 2029. The project focuses on developing deep learning-based biomarkers for optic neuropathies using retinal Optical Coherence Tomography (OCT) imaging analysis. The research will employ advanced computational techniques, including deep generative models, neural field image...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $610,000 Project Grant to The Aird effective September 1, 2025, through August 31, 2026. This award funds the development and commercialization of an Adaptive Optics Optical Coherence Tomography (AO-OCT) system designed for high-resolution, wide-field retinal imaging in rodent models, particularly mice. The primary deliverable is a portable AO-OCT imaging system featuring a...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded $571,206 to the University of Maryland, Baltimore on May 1, 2026, to support research on the development, refinement, and validation of sensitive and robust adaptive optics-optical coherence tomography (AO-OCT) biomarkers for glaucoma detection and progression monitoring. The project will deliver two primary research products: (1) validated AO-OCT biomarkers through longitudinal...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $431,750 Project Grant to the University of California, Irvine under the Vision Research program (CFDA 93.867) for the period May 1, 2026 through April 30, 2028. This award funds exploratory research investigating novel mechanisms underlying obstructive meibomian gland dysfunction (O-MGD), a condition characterized by altered meibum lipid synthesis that leads to duct dilation and dry eye disease. The research will produce...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $122,075 Project Grant to the University of California, Los Angeles (UCLA) on April 15, 2026, through the Vision Research program (CFDA 93.867) to support research on molecular gradients underlying wiring plasticity in the visual cortex. The research integrates single-cell transcriptomics, epigenomics, connectomics, and computational analysis to investigate how visual experience regulates the organization of neurons in layers...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded New York University School of Medicine a $673,747 Vision Research project grant (CFDA 93.867) commencing June 1, 2025, and concluding May 31, 2030, to develop advanced optical imaging technology for early detection of age-related macular degeneration (AMD). The research focuses on advancing visible-to-near-infrared spanning optical coherence tomography (OCT) to achieve half-micron axial resolution for retinal imaging,...
- Federal Project Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $255,722 Project Grant to the University of California, Berkeley effective September 15, 2025, with a completion date of August 31, 2027. This award funds research investigating the role and regulation of optic nerve microglia in glaucomatous neuropathy. The research will deliver scientific findings examining how lipoxin B4 (LXB4)—an endogenous neuroprotective...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $421,136 Project Grant to the University of Maryland, College Park, effective August 1, 2025, through July 31, 2027, under the Vision Research program (CFDA 93.867). This award supports research into advanced wavefront shaping techniques designed to enable high-resolution fundus imaging in patients with ocular opacities—conditions affecting the cornea and lens that currently prevent effective posterior segment eye...
The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded the University of California, Los Angeles (UCLA) a Project Grant of $722,904 beginning May 1, 2026, and extending through April 30, 2031. This award funds the "Researching OCT Biomarkers in Uveitis Clinical Trials (ROBUST)" initiative, which will conduct secondary analysis of optical coherence tomography (OCT) imaging and clinical data from four NEI-funded uveitis randomized clinical trials. The research aims to identify and validate objective OCT biomarkers—including ellipsoid zone integrity, photoreceptor layer thickness, intraretinal hyperreflective foci, choroidal thickness, and retinal layer disorganization—that can serve as prognostic indicators for uveitic macular edema (UME) and treatment response in intermediate, posterior, and panuveitis patients. This project addresses a critical gap in uveitis management by developing quantitative, non-invasive imaging biomarkers to improve clinical decision-making and patient outcomes. Uveitic macular edema is the leading cause of visual impairment and blindness in uveitis, occurring in approximately 40% of patients with these chronic forms of the disease. By leveraging existing clinical trial datasets and UCLA's expertise in image analysis and clinical trials, the research will advance objective assessment methods currently limited to subjective OCT interpretations focused on macular thickness and structural abnormalities.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $722.9k | 4/27/26 |