Project Grant R01EY037489
- The National Eye Institute awarded The Trustees of The University of Pennsylvania $719,199 on August 5, 2026, under the Vision Research program (CFDA 93.867) to advance understanding of retinal ganglion cell and optic nerve regeneration following injury and optic neuropathies. The research will employ single-cell CRISPR screening (perturb-seq) to systematically identify genes and gene combinations whose suppression most effectively promotes retinal ganglion cell and optic nerve regeneration...
- The National Eye Institute awarded the University of Pittsburgh $433,324 under the Vision Research program (CFDA 93.867) on September 1, 2026, to develop next-generation microfluidic platforms for high-throughput screening of axon growth-promoting compounds as potential regeneration therapies for glaucoma and optic neuropathies. The project focuses on addressing limitations in conventional axon growth assays by engineering microfluidic devices that enable defined chemoattractant gradients,...
- The National Eye Institute awarded Wayne State University $626,683 on July 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of polyunsaturated fatty acids in retinal pigmented epithelium pathology and outer retinal disease development. The research examines how omega-3 and omega-6 polyunsaturated fatty acids contribute mechanistically to retinal pigmented epithelium dysfunction in a transgenic mouse model (B6.TMEM135 TG) that exhibits retinal pigmented...
- The National Eye Institute awarded the University of Maryland, Baltimore $498,000 on September 30, 2025, under the Vision Research program (CFDA 93.867) to assess the retinal pigment epithelial cell mosaic through functional imaging of intracellular pigment dynamics in the living human eye. The research develops translational fluorescence lifetime imaging methods to elucidate spectral-temporal fluorescence signatures of retinal pigment granules, map the distribution of retinal pigments in vivo...
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded The Trustees of Columbia University in the City of New York $100,228 on December 1, 2026, under the Vision Research program (CFDA 93.867). The recipient will conduct preclinical research on autologous transplantation of genetically modified induced pluripotent stem cells (iPSCs) to treat autosomal dominant retinal disorders, specifically RPE65 D477G mutations causing retinitis...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $2,271,828 to The University of Texas Southwestern Medical Center on September 1, 2026, under the Vision Research program (CFDA 93.867). The recipient will conduct research into the cellular and molecular mechanisms governing optic nerve myelin integrity, with emphasis on understanding how myelin whorls—multilayered degenerative myelin structures that appear in demyelinating...
- The National Eye Institute, part of the Department of Health and Human Services National Institutes of Health, awarded $624,743 to the Regents of the University of California, doing business as University of California, Berkeley, on May 1, 2026, under the Vision Research program (CFDA 93.867). The award funds research into the function and regulation of constitutive prostaglandin D2 and DP receptor signaling in retinal health and neurodegeneration. The research investigates the physiological and...
- The National Eye Institute awarded Massachusetts Eye and Ear Infirmary $663,406 on April 1, 2026, under the Vision Research program (CFDA 93.867) to elucidate the molecular mechanisms of secondary cone degeneration in models of retinitis pigmentosa. The recipient will develop a novel AAV-based retinoic acid signaling activator and test whether it can improve photopic visual acuity in multiple mouse models of retinitis pigmentosa. The work will also aim to elucidate the molecular and cellular...
- The National Eye Institute awarded The Research Foundation For The State University Of New York $248,737 on June 1, 2026, under the Vision Research program (CFDA 93.867) to support research on the role of mitochondrial and autophagy dysfunction in regulating inflammatory processes during age-related macular degeneration pathogenesis. The award funds investigation into the deregulation of autophagy and heightened inflammation implicated in dry AMD, the leading cause of blindness in the elderly...
The National Eye Institute awarded the University of Pennsylvania $674,423 on September 1, 2026, under the Vision Research program (CFDA 93.867) to investigate the role of retinal microsomal triglyceride transfer protein (MTP) in vision and lipid homeostasis. The research examines how MTP regulates the assembly and secretion of apoprotein B-containing lipoproteins in the retinal pigment epithelium (RPE), which transport lipids and prevent pathologic lipid accumulation linked to retinal degeneration. The project uses a metabolically intact in vivo system, including an RPE-specific MTP-deficient mouse model, to demonstrate that local MTP activity maintains lipid homeostasis in both the RPE and neural retina. The work connects these findings to human vision loss in patients with age-related macular degeneration and abetalipoproteinemia, conditions associated with MTP deficiency or dysfunction. Performance runs through August 31, 2030, at the University of Pennsylvania in Philadelphia, Pennsylvania. The assistance type is a project grant under the National Eye Institute's investigator-initiated research portfolio.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $674.4k | 9/2/26 |