Project Grant R01EY036795
- Federal Project Grant Award Summary Wayne State University received a $385,000 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective August 1, 2025 through July 31, 2029. The grant supports research investigating genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research utilizes zebrafish models to compare transcriptional, cellular, and functional changes occurring during chronic and...
- Federal Grant Award Summary Wayne State University received a $428,152 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded August 1, 2025, with a completion date of July 31, 2030. This research initiative investigates the role of matriptase, a cell-surface anchored serine protease, in corneal epithelial homeostasis and repair. The project delivers basic and translational science research utilizing novel matriptase knockout mouse models and...
- Summary of Federal Project Grant Award The National Eye Institute (NEI) awarded a $422,125 Project Grant to the University of Miami's Office of Research Administration—School of Medicine on August 1, 2025, under the Vision Research program (CFDA 93.867) for a two-year project period concluding July 31, 2027. This award funds research investigating cholesterol homeostasis as a therapeutic target for demyelinating eye diseases, which are pathologies affecting the optic nerve that can cause...
- Federal Project Grant Award Summary The University of Washington, through its Office of Sponsored Programs, received a $458,288 Project Grant award dated May 1, 2026, from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867). The award funds a five-year research initiative—extending through February 28, 2030—focused on stimulating regeneration in the human retina to develop therapeutic interventions for retinal neuron loss associated with degenerative diseases such as...
- Federal Grant Award Summary The University of Washington received a $427,625 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded June 1, 2026, with completion anticipated May 31, 2028. This research award funds a two-year investigation into time-dependent nonlinearities underlying retinal responses to natural visual stimuli. The project addresses a critical gap in visual neuroscience: current mechanistic models of retinal processing,...
- Federal Project Grant Award Summary Case Western Reserve University's Office of Research Administration received a $384,422 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective June 1, 2026, through May 31, 2028. The award funds basic science research investigating the molecular mechanisms of blue light toxicity in retinal degeneration. The research deliverables include characterization of wavelength-dependent photoactivation of A2E (a...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a $638,625 Project Grant to the University of California, San Diego, effective August 1, 2025 through July 31, 2028, under the Vision Research program (CFDA 93.867). The award funds research to investigate the mechanisms of drusen formation in age-related macular degeneration (AMD), a leading cause of blindness affecting approximately 196 million people globally. The research employs a novel quartz crystal microbalance assay...
- Summary of Federal Grant Award The National Eye Institute (NEI) awarded the University of Pittsburgh a $679,650 Project Grant under the Vision Research program (CFDA 93.867) effective June 1, 2026, through May 31, 2030. The award funds research to develop and validate adaptive optics ophthalmoscopy (AOO) as a non-invasive, label-free imaging tool for real-time assessment of immune responses in posterior uveitis, an inflammatory eye condition responsible for up to 10% of blindness in the United...
- Federal Grant Award Summary Award Overview The National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) awarded a $504,304 Project Grant to Trustees of Tufts College (Tufts University School of Medicine) effective April 15, 2026, with a completion date of March 31, 2031. This project addresses age-related macular degeneration (AMD), a leading cause of vision loss in older adults, through investigation of the gut-retina axis—the mechanistic pathway by which gut microbiota...
- Federal Grant Award Summary The National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), awarded a $122,610 Project Grant to the University of Wisconsin-Madison on December 3, 2025, with completion targeted for April 30, 2028. This award funds fundamental research investigating how synaptic ribbons—specialized presynaptic structures that function as "conveyer belts" for glutamate vesicles—contribute to retinal circuit function and visual information processing....
Wayne State University received a $626,683 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded July 1, 2026, with an ultimate completion date of February 28, 2031. This award funds research investigating the role of polyunsaturated fatty acids (PUFAs) in retinal pigmented epithelium (RPE) pathology, with the objective of identifying therapeutic targets for outer retinal diseases including retinitis pigmentosa, Stargardt's disease, and age-related macular degeneration. The research utilizes a novel mouse model (B6.TMEM135 transgenic mice) to examine how omega-3 and omega-6 PUFAs mechanistically contribute to RPE dysfunction, including the investigation of oxidative stress, ferroptosis markers, cellular metabolism modifications, and genetic influences on degenerative phenotypes. The grant supports basic science research activities designed to advance understanding of molecular mechanisms underlying RPE dysfunction. Deliverables include scientific findings from experimental studies using the transgenic mouse model, characterization of PUFA regulation pathways, identification and analysis of quantitative trait loci affecting retinal PUFA metabolism, and research outcomes aimed at therapeutic target identification for outer retinal diseases. This award represents NEI's commitment to funding innovative vision research addressing critical gaps in understanding eye and visual system pathology, consistent with the program's mission to eliminate vision loss and improve quality of life through research advancement.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $626.7k | 7/3/26 |