This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $615,979 to Wayne State University to investigate a promising peptide-based combination therapy that targets hyperglycemia-responsive circuits in the cornea to prevent high glucose-induced damage and restore structure and function in the diabetic cornea. The award supports in vitro and in vivo assessments to establish the therapeutic role of the TB4 and VIP combination treatment and elucidate the...
The National Eye Institute (NEI) awarded a $176,550 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Louisville to optimize C-Met signaling to enhance corneal epithelial homeostasis. The research aims to extend C-Met receptor activity by disrupting its downregulation, with the goal of restoring corneal homeostasis following wounding. The study will investigate the role of C-Met ubiquitylation in limiting its signaling in corneal epithelial cells in...
The National Eye Institute (NEI) awarded a $586,258 Project Grant under the Vision Research program (CFDA 93.867) to Wayne State University to conduct research on the role of eosinophils in modulating the corneal response to Pseudomonas aeruginosa infection. The research, spanning from Jul 1, 2025 to Apr 30, 2029, aims to characterize the spatiotemporal distribution, phenotypic profiles, and proteomic changes of eosinophils during corneal inflammation and infection using mouse models. The...
The National Eye Institute (NEI) awarded a Project Grant (CFDA 93.867 - Vision Research) in the amount of $753,189 to Trustees of Boston University, doing business as Boston University Medical Campus, with a period of performance from August 1, 2024 to May 31, 2029. The grant will support research to identify novel therapeutic targets for corneal epithelial defects by revealing the differential roles of basal epithelial cells in the central cornea, limbus, and conjunctiva in corneal health and...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to understand the development and function of corneal lens-secreting cells in the human eye. The $543,037 award, effective September 1, 2024 through May 31, 2028, will fund investigations into the genetic and molecular mechanisms underlying corneal development and function. Key research objectives include identifying transcription factors and...
The federal Project Grant award of $433,125.00, awarded by the National Eye Institute (CFDA 93.867 Vision Research program), supports research aimed at inhibiting corneal neovascularization (CNV) by targeting tissue factor (TF). The Ohio State University will conduct studies to define dosages and time windows for systemically administering a TF-targeting agent (L-ICON3) as a monotherapy, as well as determine potential synergistic effects of L-ICON3 combined with other tissue repair factors, to...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research to investigate the relationship between myofibroblasts and alloreactive T cells in corneal transplantation. The $540,213 award to The Schepens Eye Research Institute, Inc., effective August 1, 2025 through July 31, 2030, aims to: 1) define the mechanisms by which myofibroblasts regulate alloreactive effector T cell function, and 2) define the mechanisms by...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports a research project focused on understanding genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The total award amount is $385,000.00 over a 4-year period from August 1, 2025 to July 31, 2029. The project, led by researchers at Wayne State University, aims to compare the transcriptional, cellular, and functional...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 Vision Research) provides $246,000 to The Regents of the University of California, San Francisco to conduct research on serum components that support corneal health. The goal is to define the combinations of serum factors, such as growth factors, signaling lipids, and vitamins, that can restore healthy corneal function and treat diverse ocular surface disorders. The research aims to improve the clinical use of...
The National Eye Institute (NEI) awarded a $225,772 Project Grant (CFDA 93.867 - Vision Research) to The Research Foundation For The State University Of New York, doing business as Stony Brook University, to develop a terahertz time-domain spectroscopy (THz-TDS) imaging system that can accurately measure and map corneal hydration gradients. The project aims to: Determine the accuracy of the THz-TDS corneal scanner in measuring hydration levels in corneal phantoms and ex vivo models. Evaluate the...