The University of California, San Francisco (UCSF) received a $246,000 Project Grant award from the National Eye Institute (NEI) under the federal Vision Research grant program (CFDA 93.867). The objective of this 2-year award is to define the combinations of serum components, such as growth factors, signaling lipids, and vitamins, that support corneal repair. The research seeks to characterize the bioactive serum tear components and investigate the synergistic effects of these components in an ocular surface disease model. The findings are expected to provide translational insights to improve the clinical use of blood-based treatments like autologous serum tears for diverse ocular surface disorders. This research aims to address formulation and accessibility challenges that have limited the widespread use of serum tear therapies despite their demonstrated clinical benefits.