This $543,037 federal Project Grant award, issued by the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), supports research to understand the development and function of corneal lens-secreting cells in the Drosophila corneal lens model. The research aims to: 1) identify transcription factors and chromatin changes regulating the differentiation of cone and pigment cells that secrete the corneal lens; 2) examine how the timing of cone and pigment cell differentiation, controlled by ecdysone signaling, impacts corneal lens morphology; and 3) characterize the molecular and structural components of the Drosophila corneal lens to establish its utility as a model for understanding human corneal disorders. The award was made to New York University School of Medicine, a prominent academic medical center, and runs from September 1, 2024 through May 31, 2028. The research findings may provide insights into the genetic basis of visual disorders like myopia, hyperopia, astigmatism, keratoconus, and corneal dystrophy, potentially leading to new treatment approaches.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $543.0k | 8/26/24 |