This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), aims to develop universally immune-compatible induced pluripotent stem cells (iPSCs) for regenerative therapies to treat various eye conditions. The $492,500 award, granted on January 1, 2025, supports research at The Schepens Eye Research Institute, Inc. to generate iPSCs that express peptide-free or low-affinity peptide-loaded HLA-I molecules, protecting them from...
The National Eye Institute (NEI) awarded a Project Grant (CFDA 93.867 - Vision Research) in the amount of $753,189 to Trustees of Boston University, doing business as Boston University Medical Campus, with a period of performance from August 1, 2024 to May 31, 2029. The grant will support research to identify novel therapeutic targets for corneal epithelial defects by revealing the differential roles of basal epithelial cells in the central cornea, limbus, and conjunctiva in corneal health and...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research to understand the development and function of corneal lens-secreting cells in the human eye. The $543,037 award, effective September 1, 2024 through May 31, 2028, will fund investigations into the genetic and molecular mechanisms underlying corneal development and function. Key research objectives include identifying transcription factors and...
This $148,568 Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research at Emory University to investigate the role of scleral fibroblasts in refractive development and myopia. The primary objectives are to: 1) Identify characteristics of scleral fibroblasts in mouse eyes that undergo normal refractive development versus those exposed to myopic stimuli, and 2) Determine the role of retinoic acid signaling in driving...
The federal Project Grant award of $433,125.00, awarded by the National Eye Institute (CFDA 93.867 Vision Research program), supports research aimed at inhibiting corneal neovascularization (CNV) by targeting tissue factor (TF). The Ohio State University will conduct studies to define dosages and time windows for systemically administering a TF-targeting agent (L-ICON3) as a monotherapy, as well as determine potential synergistic effects of L-ICON3 combined with other tissue repair factors, to...
This $421,600 Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) will support research at Tufts Medical Center in Boston, MA to investigate the regulatory mechanisms governing retinal neovascularization. The research aims to delineate the role of chemokine signaling in recruiting peripheral immune cells to facilitate pathological vascular growth, as well as the role of microglial complement receptors in regulating neovessel regression. The project will utilize...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), supports research to understand the role of the signaling protein SMAD4 in regulating the extracellular matrix of the corneal stroma. The $243,000 grant, awarded on February 1, 2025, will be used by the University of Cincinnati to conduct two specific aims over 2 years: Rescue the progressive corneal stromal thinning phenotype observed in TBR1 knockout mice by targeting...
This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $428,152 to Wayne State University to support research on the role of the protease matriptase in maintaining corneal epithelial barrier function and promoting corneal tissue repair. The award will fund a 5-year project to utilize mouse models and 3D cellular models of the human cornea to characterize matriptase's function in corneal homeostasis and identify its substrates and signaling...
The National Eye Institute (NEI) awarded a $586,258 Project Grant under the Vision Research program (CFDA 93.867) to Wayne State University to conduct research on the role of eosinophils in modulating the corneal response to Pseudomonas aeruginosa infection. The research, spanning from Jul 1, 2025 to Apr 30, 2029, aims to characterize the spatiotemporal distribution, phenotypic profiles, and proteomic changes of eosinophils during corneal inflammation and infection using mouse models. The...
The National Eye Institute (NEI) awarded a $176,550 Project Grant under the Vision Research federal grant program (CFDA 93.867) to the University of Louisville to optimize C-Met signaling to enhance corneal epithelial homeostasis. The research aims to extend C-Met receptor activity by disrupting its downregulation, with the goal of restoring corneal homeostasis following wounding. The study will investigate the role of C-Met ubiquitylation in limiting its signaling in corneal epithelial cells in...