This $615,979 Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), supports research to investigate a promising peptide-based combination therapy for restoring structure and function in the diabetic cornea. The key objectives are to: 1) establish the therapeutic role of TB4 and VIP as a combination treatment against diabetes-induced corneal complications; and 2) elucidate the DDR-TRP axis, a novel pathway responsive to hyperglycemic conditions in the cornea. The research approach includes in vitro assessments of corneal epithelial cells and stromal fibroblasts, as well as comprehensive in vivo studies using two mouse models of type 1 diabetes to evaluate changes in corneal structure, function, sensitivity, innervation, inflammation, and wound healing. The research aims to delineate the mechanism of diabetes-induced corneal damage and provide preclinical evidence for developing a novel therapeutic approach with significant translational potential to impact diabetic corneal complications.
Mod # | Description | Reason For Modification | Federal Obligation (Click to sort descending) | Date (Click to sort ascending) |
|---|---|---|---|---|
| Not listed | $616.0k | 4/4/25 |