Project Grant R01EY037224
- Federal Grant Award Summary New York University School of Medicine received a $285,498 Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) effective September 30, 2025, with an ultimate completion date of August 31, 2027. This research grant funds fundamental scientific investigation into corneal lens development mechanisms using Drosophila (fruit fly) as a model organism to better understand human corneal curvature disorders including...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant totaling $900,600 to The Regents of the University of California, San Francisco, with an award date of September 1, 2025, and completion date of August 31, 2027, under the Vision Research program (CFDA 93.867). This award funds research directed at understanding corneal limbal stem cells (LSCs) during wound healing processes. The project addresses the significant clinical need for restorative treatments for...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded The Schepens Eye Research Institute, Inc. a Project Grant totaling $540,213 under the Vision Research program (CFDA 93.867) to investigate the fibrosis-immunity interface in corneal transplantation. Beginning August 1, 2025, and extending through July 31, 2030, this research program will deliver scientific findings aimed at improving corneal transplant survival rates by elucidating the mechanisms by which myofibroblasts...
- Federal Grant Award Summary The University of North Texas Health Science Center at Fort Worth received a $249,000 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with completion targeted for March 31, 2029. This research initiative focuses on identifying therapeutic interventions to prevent cell death in human corneal stromal cells as a non-surgical treatment approach for keratoconus, a progressive corneal disorder...
- Federal Grant Award Summary Albert Einstein College of Medicine received a $414,711 Project Grant from the National Eye Institute (NEI) Vision Research program (CFDA 93.867), awarded June 1, 2025, with completion targeted for May 31, 2029. The award supports the development and utilization of a microphysiological system to elucidate mechanisms underlying early optic disc and stalk development, retinal ganglion cell (RGC) differentiation, axon growth, and pathfinding in human development and...
- Federal Project Grant Award Summary Tufts University School of Medicine received a $144,618 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), effective September 1, 2025 through March 31, 2028. The grant funds research investigating fucosylation as a mediator of limbal stem cell (LSC) viability. The research focuses on understanding how fucose, a monosaccharide component of the cell surface glycocalyx, influences the survival of limbal stem...
- Federal Grant Award Summary The National Eye Institute (NEI) awarded a Project Grant of $497,740 to the University of Illinois (Chicago, IL) under the Vision Research program (CFDA 93.867), effective April 1, 2026, through March 31, 2031. Under the direction of Principal Investigator Elmira Jalilian, this research project will generate scientific findings and empirical data examining neuro-epithelial interactions in corneal disease and repair, with particular focus on how corneal nerves...
- Federal Project Grant Award Summary The National Eye Institute (NEI) awarded New York University School of Medicine a $673,747 Vision Research project grant (CFDA 93.867) commencing June 1, 2025, and concluding May 31, 2030, to develop advanced optical imaging technology for early detection of age-related macular degeneration (AMD). The research focuses on advancing visible-to-near-infrared spanning optical coherence tomography (OCT) to achieve half-micron axial resolution for retinal imaging,...
- Federal Grant Award Summary ESK Therapeutics, Inc. received a $330,169 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), with performance commencing September 1, 2025 and concluding August 31, 2026. The award supports the preclinical development and commercialization of CornéaClear, a first-in-class biologic eyedrop therapeutic formulation designed to accelerate corneal wound healing and reduce scarring risk in patients with persistent corneal...
- Federal Grant Award Summary The National Eye Institute (NEI), under its Vision Research program (CFDA 93.867), awarded a $260,661 Project Grant to The Schepens Eye Research Institute, Inc. for a three-year career development initiative spanning August 1, 2025, through July 31, 2028. The award supports Dr. Levi N. Kanu's mentored research program focused on developing nanomaterial-based growth factor delivery systems to improve therapeutic outcomes for corneal disease. The research plan...
New York University School of Medicine received a $546,439 Project Grant from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867), awarded April 15, 2026, with completion anticipated by March 31, 2030. The award funds research to develop corneal stromal keratocyte modeling from human cornea organoids (HCOs) as a potential therapy for corneal scarring and keratoconus-related blindness. The research leverages HCOs generated from induced pluripotent stem cells (iPSCs) that mimic fetal corneal development and co-differentiate multiple corneal cell types within a three-dimensional extracellular matrix environment. Research products will include characterization of stromal progenitor and keratocyte-like cells within HCOs, identification of transforming growth factor-beta (TGF-β) signaling pathways that promote healthy versus fibrotic extracellular matrix production, and evaluation of HCO-derived stromal cells for integration into decellularized donor corneas. This research addresses a critical clinical need to develop donor-tissue-independent stromal therapies for corneal diseases that currently rely on limited cornea transplant availability. The project aims to establish HCOs as both a novel stromal therapy resource and a corneal surrogate model for identifying therapeutic targets that maintain regenerative extracellular matrix quality while preventing pathological fibrosis, ultimately supporting the NEI's mission to eliminate vision loss and improve quality of life through innovative vision research.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $546.4k | 4/17/26 |