The National Eye Institute (NEI) awarded a $147,486 Project Grant (CFDA 93.867 - Vision Research) to The Johns Hopkins University to evaluate the regenerative potential of human retinal ganglion cells (RGCs) and their ability to regrow the optic nerve. The project aims to explore how intrinsic factors regulate optic nerve regeneration in zebrafish, and test whether modulating these factors can stimulate optic nerve formation in human RGCs transplanted into zebrafish. This research seeks to...
This federal Project Grant award of $679,159 from the National Eye Institute (NEI), under the NIH Vision Research program (CFDA 93.867), supports research to investigate the combined effects of aging and elevated intraocular pressure on the development of glaucoma and the retinal ganglion cell (RGC) transcriptome. The research aims to identify age- and glaucoma-specific transcriptomic changes, and determine how these changes are altered by in vivo transient epigenetic reprogramming using...
This Project Grant award from the National Eye Institute (NEI), under the Vision Research program (CFDA 93.867), provides $651,846 to The Johns Hopkins University to identify gene regulatory networks controlling temporal patterning in retinal progenitor cells and neurogenic Müller glia. The research aims to determine the mechanisms by which key transcription factors regulate developmental competence, proliferation, and neurogenesis in retinal progenitor cells. Findings from this 5-year...
This $413,741 Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), will support research to investigate the genetic and epigenetic mechanisms underlying retinal development and differentiation. The research aims to provide a deeper understanding of the chromatin-based regulatory processes that govern retinal transcriptional programs and how disruptions in these core regulatory networks can lead to congenital vision disorders...
This National Eye Institute (NEI) Vision Research (CFDA 93.867) Project Grant award of $387,428 supports research to investigate fundamental mechanisms driving optic nerve sensitivity to elevated intraocular pressure (IOP) in glaucoma. The 5-year project, led by the Research Foundation for the State University of New York (Upstate Medical Center), aims to determine how transient biomechanical strains on optic nerve head astrocytes may predispose them to glaucomatous dysfunction. The research...
The National Eye Institute (NEI) awarded a $665,243 Project Grant under the Vision Research program (CFDA 93.867) to The Ohio State University for the project "Enhancement of RGC Survival and Optic Nerve Regeneration by Cytokine Polarized Myeloid Cells". The objective is to elucidate the mechanisms by which polarized bone marrow-derived myeloid cells can promote retinal ganglion cell (RGC) survival and optic nerve regeneration, with the goal of informing the development of autologous...
The National Eye Institute (NEI) awarded a $360,897 Project Grant (CFDA 93.867 Vision Research) to Human Cell Co, a for-profit biotechnology company, with a performance period from September 30, 2024 to August 31, 2025. The grant supports the development of a novel combination therapy for glaucoma, a leading cause of irreversible vision loss. Specifically, the funding will be used to determine if the combined application of a proprietary nerve growth factor (NGF) mutein, HC201, and oral...
The U.S. National Eye Institute (NEI) awarded a $499,116 Project Grant (CFDA 93.867 - Vision Research) to the University of California, San Diego (UCSD) to develop therapies that can regenerate optic nerve connections and restore vision. The key objectives are to: (1) Measure the functional recovery from long-term optic nerve grafting of neural stem cells that form neuronal relays in the injured visual system; (2) Investigate the role of guidance cues in directing the growth of these neuronal...
The National Eye Institute (NEI) awarded a $184,238 Project Grant under the Vision Research program (CFDA 93.867) to The Leland Stanford Junior University to evaluate cell transplantation therapy for retinal ganglion cell (RGC) protection and integration in a neurofibromatosis type-1 (NF1) optic glioma animal model. The research aims to 1) assess the functional impact of RGC loss during NF1 optic glioma progression and the effects of RGC transplantation on the remaining retinal circuitry, and 2)...
The National Eye Institute (NEI) awarded a $714,141 Project Grant (CFDA 93.867 - Vision Research) to the University of Utah to conduct research on the mechanisms of hedgehog signaling in vertebrate eye development. The project aims to: (1) investigate how the G protein coupling and PKA-binding pathways of the Smoothened (SMO) receptor regulate retinal development and ganglion cell differentiation using human retinal organoid models; (2) assess the impact of these SMO-dependent pathways on...