Project Grant R01EY036070
- This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $502,677 to The Leland Stanford Junior University (Stanford University) to develop chemical modulators of endoplasmic reticulum (ER) stress as neuroprotective treatments for glaucoma. The research aims to optimize promising ER stress modulator compounds identified through high-throughput screening, evaluate their efficacy in mouse models of glaucoma, and...
- The National Eye Institute (NEI) awarded a $451,000 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Regents of the University of California, San Francisco (UCSF) to conduct a multimodal characterization of a novel inherited mouse model of glaucoma. The research aims to evaluate structural and functional changes in the mouse model, including axonal degeneration, retinal ganglion cell loss, dendritic changes, and neuroinflammatory responses. It will also identify...
- The U.S. National Eye Institute (NEI) awarded a Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Leland Stanford Junior University (Stanford University) in the amount of $257,785. The grant supports research to investigate the role of DNA damage response pathways, specifically the inhibition of checkpoint kinase 1 (CHK1), in enhancing retinal ganglion cell survival and promoting neuroprotection for the treatment of traumatic optic neuropathy (TON). The...
- This Project Grant award for $679,159 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research on in vivo epigenetic reprogramming of retinal ganglion cells (RGCs) in aging mice with glaucoma. The research aims to identify new therapeutic targets for glaucoma that can protect and rejuvenate RGCs, which are specifically targeted and damaged in this disease leading to vision loss. The 4-year project, awarded to The Schepens Eye...
- The U.S. National Eye Institute awarded a $1,397,496 Project Grant under its Vision Research federal grant program (CFDA 93.867) to The Leland Stanford Junior University. The grant, with an award date of August 1, 2025 and an ultimate completion date of March 31, 2030, will support research to identify the mechanism underlying the interplay between the loss of the ARMC9 gene and impaired mitochondrial function in the formation of cilia in Joubert Syndrome, a rare inherited form of retinal...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, provides $385,000.00 in funding to Wayne State University to conduct research on genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research aims to understand, prevent, and treat vision-related conditions and diseases, a focus area of NEI's Vision Research federal grant program (CFDA 93.867). The study will compare...
- This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), provides $247,387 to Stanford University to establish a comprehensive strategy for recruiting, training, and retaining clinician-scientists in ophthalmology research. The overarching objectives are to educate and develop the next generation of clinician-scientists focused on vision-related diseases and disorders, and to enhance research capabilities within ophthalmology...
- The National Eye Institute (NEI), a part of the U.S. Department of Health and Human Services, awarded a $617,743 Project Grant under the Vision Research program (CFDA 93.867) to The Leland Stanford Junior University to study the effects of ultrasound stimulation on retinal ganglion cell activity. The goal is to use a newly developed transparent ultrasound transducer, together with in vivo optical imaging, to understand the biophysical mechanisms and therapeutic potential of ultrasound for...
- This $460,625 Project Grant was awarded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867) to Yale University. The grant will fund research to investigate the cellular and synaptic mechanisms underlying changes in retinal ganglion cell (RGC) activity following optic nerve injuries in mouse models of glaucoma. Specifically, the project aims to (1) determine the underlying mechanisms for altered RGC activity after increased intraocular pressure or...
- This $617,201 Project Grant awarded by the National Eye Institute's Vision Research program aims to leverage innovative tools from engineering, AI, and advanced optical coherence tomography (OCT) imaging to directly observe and unveil the specific mechanical insults to retinal ganglion cell axons that contribute to vision loss progression in glaucoma patients. The research team from Emory University intends to monitor glaucoma patients longitudinally to identify where these axonal insults,...
The National Eye Institute (NEI), under the Department of Health and Human Services, has awarded a $695,050 Project Grant to The Leland Stanford Junior University (Stanford University) to investigate the role of cholinergic dysfunction in the pathogenesis of glaucoma. The grant, funded through the NEI's Vision Research program (CFDA 93.867), aims to leverage advanced magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques to identify and quantify cholinergic changes in the visual pathways of glaucoma patients and experimental rat models. The research seeks to understand how impairments in the cholinergic nervous system contribute to structural and functional damage associated with glaucoma, with the goal of advancing the understanding of this leading cause of vision loss. The project will be conducted at Stanford University over a period of approximately 5 years, from September 2025 to March 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $695.1k | 9/19/25 |