This is a Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), in the amount of $249,000.00. The grant will fund research to investigate the molecular mechanisms that regulate the expression of phototransduction genes in mammalian rod photoreceptors. The research aims to elucidate how transcriptional elongation and mRNA processing are coupled to enhance the efficiency and accuracy of mRNA maturation, and how defects in these...
The National Eye Institute (NEI) awarded a $862,580 Project Grant under the Vision Research program (CFDA 93.867) to The Regents of the University of Colorado, doing business as the University of Colorado-Denver. The grant, titled "The Aging Eyes Study: Mitochondrial Dysfunction as a Driver of Age-Related Vision Loss," will run from Sep 30, 2024 to Sep 29, 2026. The project aims to identify the role of mitochondrial function and genetics in the etiology of aging-related eye diseases,...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $357,056 to The Leland Stanford Junior University (Stanford University) to conduct research on retinal circuit integration and degeneration in neurofibromatosis type-1 (NF1). The key objectives are to: Evaluate the functional impact of retinal ganglion cell (RGC) loss during NF1 progression and the impact of RGC transplantation on the remaining retinal circuitry. Examine if transplanted RGCs can...
The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $606,092 Project Grant through the Vision Research program (CFDA 93.867) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The grant, awarded on January 1, 2025, supports a 4-year research project to investigate the development of the preferred retinal locus (PRL) in individuals with central vision loss due to macular diseases...
The National Eye Institute (NEI) awarded a $624,230 Project Grant under the Vision Research program (CFDA 93.867) to the University of California, Los Angeles (UCLA) for the period of May 1, 2025 to April 30, 2029. The grant supports research to investigate the physiology of retinal degeneration and how the retina maintains visual processing as photoreceptors are lost. Key objectives include documenting changes in rod function and connectivity to bipolar cells, and exploring the plasticity and...
This Project Grant award of $620,149 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports a multi-center research program to develop advanced genome editing technologies for modifying critical genetic risk factors associated with age-related macular degeneration (AMD). The research team, led by the University of Iowa, will conduct base editing and prime editing of AMD risk loci in human cells, including induced pluripotent stem...
This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), provides $247,387 to Stanford University to establish a comprehensive strategy for recruiting, training, and retaining clinician-scientists in ophthalmology research. The overarching objectives are to educate and develop the next generation of clinician-scientists focused on vision-related diseases and disorders, and to enhance research capabilities within ophthalmology...
This Project Grant award from the National Eye Institute (NEI) under the Vision Research program (CFDA 93.867) provides $388,750 to the University of Wisconsin-Madison to investigate the role of mitochondrial dynamics in rod photoreceptor cells. The researchers will test hypotheses related to how mitochondrial fusion and fission processes are critical for maintaining the structure, metabolic status, and health of these energy-intensive retinal neurons. The project aims to provide novel...
This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $240,713 to investigate the role of the nuclear-encoded humanin isoform MTRNR2L1 in the pathogenesis of age-related macular degeneration (AMD), a leading cause of blindness. The research aims to elucidate whether MTRNR2L1 is a protein-coding gene or long non-coding RNA, and to examine its function in regulating mitochondrial activity and cell survival in retinal pigment epithelial cells under stress...
This Project Grant award, funded by the National Eye Institute (NEI) under the Vision Research federal grant program (CFDA 93.867), supports a research project focused on understanding genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The total award amount is $385,000.00 over a 4-year period from August 1, 2025 to July 31, 2029. The project, led by researchers at Wayne State University, aims to compare the transcriptional, cellular, and functional...