Project Grant K08EY037381
- The National Eye Institute (NEI), under the Department of Health and Human Services, has awarded a $695,050 Project Grant to The Leland Stanford Junior University (Stanford University) to investigate the role of cholinergic dysfunction in the pathogenesis of glaucoma. The grant, funded through the NEI's Vision Research program (CFDA 93.867), aims to leverage advanced magnetic resonance imaging (MRI) and spectroscopy (MRS) techniques to identify and quantify cholinergic changes in the visual...
- The U.S. National Eye Institute awarded a $1,397,496 Project Grant under its Vision Research federal grant program (CFDA 93.867) to The Leland Stanford Junior University. The grant, with an award date of August 1, 2025 and an ultimate completion date of March 31, 2030, will support research to identify the mechanism underlying the interplay between the loss of the ARMC9 gene and impaired mitochondrial function in the formation of cilia in Joubert Syndrome, a rare inherited form of retinal...
- This federal Project Grant award from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), provides $502,677 to The Leland Stanford Junior University (Stanford University) to develop chemical modulators of endoplasmic reticulum (ER) stress as neuroprotective treatments for glaucoma. The research aims to optimize promising ER stress modulator compounds identified through high-throughput screening, evaluate their efficacy in mouse models of glaucoma, and...
- This Project Grant award from the National Eye Institute (NEI), under the federal Vision Research program (CFDA 93.867), provides $247,387 to Stanford University to establish a comprehensive strategy for recruiting, training, and retaining clinician-scientists in ophthalmology research. The overarching objectives are to educate and develop the next generation of clinician-scientists focused on vision-related diseases and disorders, and to enhance research capabilities within ophthalmology...
- This Project Grant award from the National Eye Institute (NEI), part of the U.S. Department of Health and Human Services, provides $385,000.00 in funding to Wayne State University to conduct research on genetic and glial support mechanisms in acute and chronic models of photoreceptor degeneration. The research aims to understand, prevent, and treat vision-related conditions and diseases, a focus area of NEI's Vision Research federal grant program (CFDA 93.867). The study will compare...
- This federal Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides $357,056 to The Leland Stanford Junior University to conduct research on retinal circuit integration and degeneration in neurofibromatosis type-1 (NF1). The key objectives are to: 1) Evaluate the functional impact of retinal ganglion cell (RGC) loss during NF1 progression and the effects of RGC transplantation on the remaining retinal circuitry, and 2) Examine if transplanted RGCs can form...
- This Project Grant award from the National Eye Institute (CFDA 93.867 - Vision Research) provides funding to researchers at the University of California, San Francisco (UCSF) to study the neural mechanisms underlying visual processing and behavior after photoreceptor degeneration. The $237,588 award, spanning June 2025 through December 2027, will leverage the vertical optokinetic reflex (OKR) - a visual behavior that tracks global motion - to investigate how cone degeneration disrupts noise...
- This Project Grant award for $679,159 from the National Eye Institute (NEI), under the Vision Research federal grant program (CFDA 93.867), supports research on in vivo epigenetic reprogramming of retinal ganglion cells (RGCs) in aging mice with glaucoma. The research aims to identify new therapeutic targets for glaucoma that can protect and rejuvenate RGCs, which are specifically targeted and damaged in this disease leading to vision loss. The 4-year project, awarded to The Schepens Eye...
- The National Eye Institute (NEI), under the U.S. Department of Health and Human Services, awarded a $606,092 Project Grant through the Vision Research program (CFDA 93.867) to The Regents of the University of California, doing business as the University of California, Berkeley (UC Berkeley). The grant, awarded on January 1, 2025, supports a 4-year research project to investigate the development of the preferred retinal locus (PRL) in individuals with central vision loss due to macular diseases...
- The National Eye Institute (NEI) awarded a $451,000 Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Regents of the University of California, San Francisco (UCSF) to conduct a multimodal characterization of a novel inherited mouse model of glaucoma. The research aims to evaluate structural and functional changes in the mouse model, including axonal degeneration, retinal ganglion cell loss, dendritic changes, and neuroinflammatory responses. It will also identify...
The U.S. National Eye Institute (NEI) awarded a Project Grant under the Vision Research federal grant program (CFDA 93.867) to The Leland Stanford Junior University (Stanford University) in the amount of $257,785. The grant supports research to investigate the role of DNA damage response pathways, specifically the inhibition of checkpoint kinase 1 (CHK1), in enhancing retinal ganglion cell survival and promoting neuroprotection for the treatment of traumatic optic neuropathy (TON). The research aims to uncover novel mechanisms of retinal ganglion cell neuroprotection and identify new therapeutic targets for TON, which could potentially be applied to other optic neuropathies. The project period runs from September 1, 2025 to August 31, 2030.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $257.8k | 8/7/25 |