Project Grant R01DK142606

Award Date 7/1/25
Completion Date 4/30/28
Dollars Obligated $323K
Federal Grant Program
93.847
Assistance Type
Project Grant
Place of Performance
Minnesota, USA
Similar Awards
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK, CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $410,000.00 to The University of Texas Southwestern Medical Center to study the effects of glucagon-like peptide 1 (GLP-1) receptor agonists and brain-derived GLP-1 on the activity of neuropeptide Y/agouti-related peptide (NPY/AGRP) neurons and their impact on metabolism. The research aims to define the...
This Project Grant award, totaling $2,060,811, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award aims to explore the role of Activin Type II Receptor (ACTRII) signaling in regulating muscle hypertrophy, obesity, and weight loss, particularly in combination with GLP-1/GIP receptor agonists. The research will investigate the systemic effects of ACTRII...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research) provides $2,075,497 to the University of Texas Health Science Center at San Antonio to conduct a 4-year study on the glycemic and weight loss effects of the drug semaglutide in patients with spinal cord injury and type 2 diabetes. The study aims to evaluate whether semaglutide improves glucose tolerance, beta-cell...
This $475,605 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to definitively evaluate gastric dysrhythmia as a disease mechanism underlying functional dyspepsia and chronic nausea/vomiting syndromes, which affect over 10% of the population. The project will apply a novel non-invasive diagnostic approach called Body...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund a $319,990 research study to evaluate the use of continuous glucose monitoring (CGM) and personalized nutrition therapy for improving glycemic control in adults with type 2 diabetes mellitus. The study will enroll 72 participants in a 12-week randomized controlled trial to compare...
The federal Project Grant award F31DK138767, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research), will support research conducted by the University of Alabama at Birmingham (UAB) to assess the mechanistic relationships between the activity of neurons in the central amygdala and the effects of glucagon-like peptide-1 receptor (GLP-1R) agonism. The $120,792 award, with a period of...
This $800,000 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will support research at Beth Israel Deaconess Medical Center, Inc. (Bidmc) to develop new combinatorial pharmacology approaches for regulating multiple neuron types in the brain to effectively promote satiety and reduce body weight in mouse models of obesity. The research aims to...
This Project Grant award of $659,199 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate a novel pathway by which hepatocyte-derived GDF15 improves obesity-associated insulin resistance independent of body weight loss and GDF15 receptor signaling. The research aims to characterize the structural basis and functional consequences of GDF15...
This federal Project Grant award in the amount of $640,762.00 was issued by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award, with a start date of September 15, 2024 and an ultimate completion date of June 30, 2029, will fund research conducted by the Scripps Research Institute in La Jolla, California to investigate the interorgan communication mechanisms between...
The Project Grant award of $666,890, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program), supports a parallel-group randomized controlled trial to evaluate the efficacy of pioglitazone versus empagliflozin for treating diabetes mellitus associated with chronic pancreatitis and recurrent acute pancreatitis (CP-DM). The study, titled "PEP-DM Trial," will be conducted at the...

This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports a randomized, placebo-controlled trial to investigate the effects of long-acting GLP-1 or dual incretin (GLP-1 and GIP) modulation on gastrointestinal functions and relationship to weight loss. The total funding amount is $322,800.00, with an award date of July 1, 2025, and an ultimate completion date of April 30, 2028. The trial will be conducted by the Mayo Clinic, a renowned non-profit academic medical center, and aims to compare the effects of weekly subcutaneous semaglutide, tirzepatide, and placebo on gastric emptying, accommodation, and satiation in overweight/obese adults. The study seeks to document heterogeneity in the effects, potential for tachyphylaxis, and persistence of effects after stopping treatment, which will inform the design of future clinical trials comparing these two incretin-based agents.

Generated 7/15/25, 4:59 AM