Assessing mechanistic relationships of central amygdala neuron activity and glucagon-like peptide-1 receptor agonism
Ended Project Grant Awarded Last action
- Award ID
- F31DK138767
- Recipient
-
University Of Alabama At Birmingham UEI YND4PLMC9AN7
- Awarding agency
-
National Institute of Diabetes and Digestive and Kidney Diseases
National Institutes of Health, Department of Health and Human Services
- Obligated
- $120,792
Award facts
- Assistance listing
- 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research
- Completion date
- Place of performance
- Birmingham, AL 35294, USA
Award details come from USAspending.gov.
Description
- Abstract
- Obesity and diabetes are an epidemic in the united states with more than third of US adults now defined as obese. Some of the most effective therapies to manage glucose homeostasis and weight target the glucagon- like peptide 1 receptor (GLP-1R). Many studies demonstrate that systemic GLP-1R agonists produce changes in appetite and hypophagia through the activation of GLP-1RS in the brain, where their expression is widespread. Recent efforts to characterize the role of GLP-1RS in specific brain nuclei and circuits have mainly focused on the hypothalamus and hindbrain, whereas the function of GLP-1RS in limbic systems like the amygdala have received less attention and study. The amygdala, the brain's emotional processing core, is well known for its role in fear and anxiety, but recent data from our lab and others have demonstrated a clear role for positive valence, promoting appetitive food-seeking behavior, and driving food intake. In a recent publication, our lab described the expression of GLP-1RS in the central subnucleus of the amygdala (CEA) and characterized the neural physiology of GLP-1R-expressing neurons. In this fellowship, we will pursue a functional analysis of 1) GLP-1RS on the control of neural activity in the CEA and 2) determine the requisite role of CEA neural activity-changes on the hypophagic actions of peripherally administered GLP-1R agonists. Our studies will have important implications for understanding the cellular and molecular mechanism of action of now widely prescribed obesity and type II diabetes therapeutics.
Transactions
| Action | Obligated | Date |
|---|---|---|
| Amendment | $0 | |
| Amendment | $0 | |
| Amendment | $40,264 | |
| Amendment | $40,264 | |
| Amendment | $0 | |
| Amendment | $40,264 | |
| Original award | $0 |
Quick answers
Who received award F31DK138767?
F31DK138767 was awarded to University Of Alabama At Birmingham by National Institute of Diabetes and Digestive and Kidney Diseases (National Institutes of Health) on December 1, 2024.
How much is award F31DK138767 worth?
$120,792 has been obligated on F31DK138767.
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