This federal Project Grant award of $502,233 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to understand the neuron populations in the nucleus of the solitary tract (NTS) that mediate both aversive and non-aversive suppression of food intake, and how they contribute to long-term energy balance regulation. The research aims to...
This $176,500 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research at the University of Washington to investigate the role of hypothalamic microglia and perineuronal nets in obesity pathogenesis. The key objectives are to: 1) quantify how microglia regulate the turnover of perineuronal nets in the arcuate nucleus of the hypothalamus, 2)...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $450,000.00 to the Pennington Biomedical Research Center to elucidate the roles of the protein KAT8 in adipocytes (fat cells) and its impact on lipid metabolism, insulin resistance, and systemic metabolic health. The primary objectives of this 5-year research project are to...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $509,969 to support research on the role of the ANO4 ion channel in regulating feeding behavior, body weight, and glucose homeostasis. The primary objectives are to: Determine the physiological relevance of ANO4-expressing neurons in the area postrema of the hindbrain in controlling...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), is providing $659,199 to the University of Pittsburgh to investigate a novel pathway by which the protein GDF15 produced by liver cells can improve insulin resistance associated with obesity, independent of GDF15's effects on body weight. The research aims to determine if endogenous GDF15 from...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a five-year, $595,858 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Regents of the University of Michigan. The grant supports research to investigate the role of hypothalamic SH2B1 neurocircuits and SH2B1 signal transduction pathways in obesity and metabolic disease. Key objectives include determining whether the PVHSH2B1-DRN circuit mediates...
This Project Grant award, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the pathophysiological mechanisms of the brain's endogenous glucagon-like peptide 1 (GLP-1) system in the context of diet-induced obesity. The total funding amount is $655,971.00 and the award period runs from August 5, 2024 to June 30, 2029. The research...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Arizona State University (ASU) a $1,040,519 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund a 5-year research project to investigate the role of the protein JMJD3 in regulating leptin signaling and energy homeostasis in the hypothalamus. The project aims to: 1) Examine whether hypothalamic JMJD3 protects against obesity through an...
This federal Project Grant award of $800,000.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant will fund research conducted by the Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts to develop a novel computational pharmacology approach for coordinating the activity of multiple neuron types in the brain to regulate energy...
This $621,812 federal project grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to elucidate the neural circuitry regulating feeding behavior and body weight control. The key objectives are to 1) systematically dissect which downstream projections of ventral subiculum (VSUB) neurons mediate anorexigenic effects, 2) examine the role of...
This Project Grant award in the amount of $640,762 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to define the network of secreted proteins that facilitate communication between the intestine and adipose (fat) tissue, and investigate how disruptions in this interorgan communication network contribute to obesity and related metabolic disorders.
The key goals of this 5-year research project are to: 1) Establish the interorgan circuitry of intestine-to-visceral and subcutaneous fat communication during obesity development; 2) Determine the impact of intestine-secreted proteins on fat tissue function and metabolic adaptation in obesity; and 3) Define the regulation of fat tissue function, metabolic homeostasis, and obesity progression by the intestine-secreted protein Plexin-B2. The research leverages a novel transgenic mouse model to comprehensively identify secreted proteins trafficked from the intestine to distal tissues. The findings aim to uncover novel mechanisms by which the intestine modulates fat tissue metabolism and whole-body energy homeostasis.