Project Grant R01DK140071
- This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research on the role of substance P and its receptor MRGPRX2 in the pathophysiology of irritable bowel syndrome (IBS). The Regents of the University of Michigan, through its Office of Research and Sponsored Projects, will conduct the research project from June 2025 to May 2027. The...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $594,956 to the University of South Florida to conduct research on the mechanisms underlying stretch-evoked activation of esophageal vagal afferents. The goal is to determine the mechanosensitive channels and sodium channels responsible for transducing esophageal stretch into vagal afferent...
- This federal Project Grant award of $726,140.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to elucidate the neural circuits and cellular mechanisms underlying visceral pain processing in the spinal cord and brainstem, with the goal of advancing understanding and treatment of visceral pain conditions such as irritable bowel syndrome,...
- This $136,025 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research at New York University (NYU) to investigate the impact of gut epithelial serotonin on the function of afferent neurons and visceral pain signaling. The goal is to determine how modulation of epithelial serotonin could be leveraged as a potential pain therapy for irritable bowel...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through its Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $784,966 project grant to Brandeis University to investigate the sensory functions of pharyngeal enteric neurons in the nematode C. elegans. The 5-year project, starting on Sep 15, 2025 and ending on Jun 30, 2030, aims to study how enteric neurons detect and respond to internal chemical and mechanical cues, and how...
- This $2,557,146 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was made to the Board of Regents of the Nevada System of Higher Education (UEI: WLDGTNCFFJZ3), operating through the University of Nevada, Reno, and will fund research to explore novel targets for gastrointestinal hormones and neuropeptides in the regulation of...
- This federal Project Grant award of $524,837 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is supporting research to investigate the role of enteric glial mechanotransduction and the impact of mechanical stress on postoperative ileus (POI) and postoperative gastrointestinal dysfunction (POGD). The research aims to better understand the pathogenic mechanisms of POI in...
- This $446,875 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research on the role of the MRGPRX2 receptor in mast cells and its contribution to the pathogenesis of ulcerative colitis. The project aims to utilize CRISPR/Cas9 gene editing to replace the mouse MRGPRB2 receptor with the human MRGPRX2 receptor in mice, in order to better model the human condition. The research seeks to understand how...
- This federal Project Grant award of $161,695 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports research on the role of purinergic signaling in intestinal inflammation and wound healing. The principal objective is to elucidate how the purinergic receptor P2Y1 expressed in intestinal epithelial cells influences the inflammatory response and repair processes during colitis. The research...
- This federal Project Grant award of $1,222,594.00, provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research investigating the role of glutathione peroxidase 3 (GPX3) in regulating esophageal epithelial remodeling, subepithelial fibrosis, and eosinophil recruitment in eosinophilic esophagitis (EoE). The research, led by the primary awardee Vanderbilt...
This Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the MRGPRX4 receptor in mediating bile acid-induced activation and sensitization of esophageal nociceptive C-fibers. The $565,338 award will support a 5-year research project at The Johns Hopkins University to characterize the expression of MRGPRX4 in esophageal afferent C-fiber neuron subtypes and determine the receptor's contribution to PPI-refractory esophageal nociception. The overarching goal is to enhance understanding of the underlying mechanisms of bile acid-induced esophageal nociceptive sensations, which are common in many esophageal disorders but often refractory to current acid-inhibition treatments.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | ($32k) | 9/16/25 | ||
| Not listed | $596.9k | 8/20/25 |