Project Grant R21AI190597
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $409,320.00 Project Grant to the University of California, San Diego (UCSD) to conduct research on immune adaptations in acute pouchitis, a common inflammatory condition affecting patients with ulcerative colitis. The grant, awarded on July 17, 2025, will support UCSD's use of single-cell RNA-sequencing and spatial transcriptomics to...
- This federal Project Grant award of $1,024,897.00 from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) will fund research at the University of Pennsylvania to dissect the role of innate immune cell responses, particularly inflammatory monocytes and neutrophils, in controlling intestinal and systemic Yersinia infection. The research aims to define how a monocyte-driven TNF-IL-1 signaling circuit mediates control of Yersinia...
- The federal Project Grant award of $3,204,624.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research CFDA program, supports research to define the molecular and cellular mechanisms of non-canonical inflammasome responses to lipopolysaccharide (LPS) in mice and humans. The research aims to provide essential insight for developing improved therapeutics to reduce human sepsis, as well as immune adjuvants to enhance host...
- The National Institute of Allergy and Infectious Diseases (NIAID) awarded a $375,000 Project Grant under the Allergy and Infectious Diseases Research program (CFDA 93.855) to the University of South Florida (USF) to study the functions of messenger ribonucleoprotein (mRNP) granules in regulating mRNA metabolism in the malaria parasite Plasmodium falciparum. The project, running from Jun 10, 2025 to May 31, 2030, aims to identify mRNP markers, characterize their protein and mRNA compositions, and...
- The National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research federal grant program (CFDA 93.855), awarded a $109,076 project grant to The Trustees of the University of Pennsylvania, doing business as Clinical Practices of the University of Pennsylvania. The grant supports research on T cell trafficking to the small intestine during Cryptosporidium infection. The research aims to investigate the effect of Cryptosporidium infection on...
- This federal Project Grant award for $223,500.00 from the National Institute of Allergy and Infectious Diseases (NIAID) under the Allergy and Infectious Diseases Research program (CFDA 93.855) aims to advance scientific understanding of mast cell functions and inflammatory responses. The research will investigate regulatory pathways that limit mast cell activation, with a focus on the role of the ITCH ubiquitin ligase enzyme in controlling inflammation and restoring homeostasis. The project,...
- This Project Grant award of $578,093.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research program (CFDA 93.855), supports research to elucidate the structure and function of a novel damage-associated molecular pattern (DAMP) receptor, CLEC17A, and its murine homolog CD209f/g, and their common ligand, GAPDH, in human and mouse innate immune systems. The central hypothesis is that these receptors on innate immune cells...
- This $2,893,480 Project Grant award from the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) aims to investigate how dietary fat intake impacts intestinal inflammation associated with inflammatory bowel diseases (IBDs) like ulcerative colitis and Crohn's disease. The research will focus on understanding how excessive dietary fat disrupts the metabolism of the short-chain fatty acid butyrate in colonocytes, leading to increased...
- This $200,000 Project Grant was awarded by the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research Federal Grant Program (CFDA 93.855), to Northwestern University for the project "Targeting MicroRNAs to Modulate Neutrophil Trafficking and Improve Resolution of Gut Inflammation." The research aims to identify novel microRNAs that regulate neutrophil transmigration across the endothelial barrier during gut inflammation, with...
- This Project Grant award of $3,022,197.00 from the National Institute of Allergy and Infectious Diseases (NIAID), under the Allergy and Infectious Diseases Research (CFDA 93.855) program, will fund a study on the role of regulatory T (Treg) cells and the IL-27 cytokine in immune regulation and inflammatory bowel disease. The research team at the University of California, San Diego will employ molecular, biochemical, and immunological approaches to examine the mechanisms driving the expression of...
This $446,875 Project Grant awarded by the National Institute of Allergy and Infectious Diseases (CFDA 93.855 - Allergy and Infectious Diseases Research) supports research on the role of the MRGPRX2 receptor in mast cells and its contribution to the pathogenesis of ulcerative colitis. The project aims to utilize CRISPR/Cas9 gene editing to replace the mouse MRGPRB2 receptor with the human MRGPRX2 receptor in mice, in order to better model the human condition. The research seeks to understand how MRGPRX2 phosphorylation and desensitization modulates the disease outcome in ulcerative colitis. The award was made to the University of Pennsylvania, a leading academic research institution, and has a performance period from August 2025 to July 2027.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $446.9k | 8/11/25 |