This Project Grant award of $117,000.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) supports research to investigate the role of substance P-mediated activation of mast cells in driving visceral hypersensitivity and barrier dysfunction in irritable bowel syndrome (IBS). The objective is to delineate the underlying mechanisms of bidirectional crosstalk between sensory...
This Project Grant award of $1,461,766.00 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research on the molecular and cellular mechanisms underlying visceral pain and cross-organ sensitization. The research will focus on understanding the role of MRGPRB2+ mast cell-TRPV1+ nociceptor clusters in bladder pain and bladder-colon cross-sensitization. Key...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), will fund research to investigate the role of urothelial cells in bladder sensory function and pain signaling. The $521,019 award to The Medical College of Wisconsin, Inc. aims to functionally and molecularly identify the sensory neuron populations that respond to urothelial cell...
The federal Project Grant award R01DK142845, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research on the interplay between brain oxytocin and corticotropin-releasing factor (CRF) systems in stress-related visceral analgesia versus hyperalgesia, and its implications for irritable bowel syndrome (IBS). The $647,290 award, with a project period from Jul...
This $625,060 federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) will fund research to elucidate the roles of distinct spinal cord cell types in mediating interstitial cystitis (IC)/bladder pain syndrome (BPS). The research, conducted by The Washington University in St. Louis, will use chemogenetics and optogenetics approaches to determine the...
This federal Project Grant award of $524,837 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is supporting research to investigate the role of enteric glial mechanotransduction and the impact of mechanical stress on postoperative ileus (POI) and postoperative gastrointestinal dysfunction (POGD). The research aims to better understand the pathogenic mechanisms of POI in...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $594,956 to the University of South Florida to conduct research on the mechanisms underlying stretch-evoked activation of esophageal vagal afferents. The goal is to determine the mechanosensitive channels and sodium channels responsible for transducing esophageal stretch into vagal afferent...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $546,503.00 to Duke University to conduct research on how the gut senses and communicates bitter stimuli to the brain. The research aims to determine how specialized gut cells called neuropod cells detect bitter compounds through taste receptors and signal this information to...
This federal Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) supports a 5-year research program focused on defining novel neuro-immune pathways that regulate gut physiology. The $168,296 award to Weill Medical College of Cornell University aims to investigate the role of enzymes in group 3 innate lymphoid cells (ILC3s) and their impact on inflammatory bowel disease (IBD) and...
This $475,605 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to definitively evaluate gastric dysrhythmia as a disease mechanism underlying functional dyspepsia and chronic nausea/vomiting syndromes, which affect over 10% of the population. The project will apply a novel non-invasive diagnostic approach called Body...