This Project Grant award, with a total funding amount of $332,350.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award will support research to investigate the mechanisms of mechanosensation and inflammation-induced hypersensitivity in sensory neurons that innervate the colon, with the goal of revealing potential therapeutic targets for abdominal...
The University of Connecticut received a $649,376 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) to develop an objective, integrated multimodal electrophysiological (OIME) index for quantifying visceral pain associated with irritable bowel syndrome (IBS). The project aims to leverage wearable sensing of electrodermal activity, electrocardiogram, and abdominal...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $726,140 Project Grant (93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) to the Icahn School of Medicine at Mount Sinai for a 1-year research project titled "Spinal Circuit Mechanisms of Visceral Sensory Transmission and Regulation". The objective is to elucidate the neural circuits and cellular mechanisms underlying visceral pain processing, with a focus on glutamatergic TACR3+...
This $730,883 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award supports research at the Icahn School of Medicine at Mount Sinai to investigate the molecular and cellular mechanisms underlying bladder pain and cross-organ sensitization between the bladder and colon. Key research objectives include: Using chemogenetic and...
This $524,837 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research by The Ohio State University to better understand the role of enteric glial mechanotransduction and mechanical stress in postoperative ileus (POI) and postoperative gastrointestinal dysfunction (POGD). The research aims to: 1) Determine the role of the glial...
This $151,808 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), supports research to investigate the role of the neuropeptide adrenomedullin 2 (ADM2) in regulating intestinal inflammation and tissue protection. The project, conducted by Weill Medical College of Cornell University, aims to generate a detailed understanding of how the ADM2-ADM2 receptor...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), provides $604,082 to Duke University to assess the efficacy of psyllium fiber in reducing fructan-induced gastrointestinal symptoms in children with irritable bowel syndrome (IBS). The project aims to: 1) investigate the effect of two doses of psyllium given with a fructan meal on microbial...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $664,163 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to the Icahn School of Medicine at Mount Sinai. The project aims to investigate the regulation of CD39 expression in gamma delta intraepithelial lymphocytes (GD IELs) and its influence on GD IEL function and metabolism in the context of inflammatory bowel disease (IBD). The research will...
The Project Grant award R01DK140854, totaling $637,000.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by Michigan State University to explore the production and bioactivity of novel "microbially conjugated bile acids" (MCBAs) produced by the gut microbiome, and how they may affect disease outcomes in a mouse model of...
This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) totaling $151,643 supports research to develop proteolysis targeting chimeras (PROTACs) that can stabilize hypoxia-inducible factors (HIFs) for the treatment of inflammatory bowel disease (IBD). The research aims to elucidate the role of PROTAC-induced HIF stabilization in enhancing intestinal...