Project Grant K01DK144656
- This federal Project Grant award of $726,140.00 was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant aims to elucidate the neural circuits and cellular mechanisms underlying visceral pain processing in the spinal cord and brainstem, with the goal of advancing understanding and treatment of visceral pain conditions such as irritable bowel syndrome,...
- This federal Project Grant award of $117,000 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research) will support research on the role of substance P and its receptor MRGPRX2 in the pathophysiology of irritable bowel syndrome (IBS). The Regents of the University of Michigan, through its Office of Research and Sponsored Projects, will conduct the research project from June 2025 to May 2027. The...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through its Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $784,966 project grant to Brandeis University to investigate the sensory functions of pharyngeal enteric neurons in the nematode C. elegans. The 5-year project, starting on Sep 15, 2025 and ending on Jun 30, 2030, aims to study how enteric neurons detect and respond to internal chemical and mechanical cues, and how...
- This $647,290 federal Project Grant was awarded on July 1, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the University of California, Los Angeles (UCLA) to study the interplay between brain oxytocin and CRF (corticotropin-releasing factor) systems in stress-related visceral analgesia versus hyperalgesia, and the...
- This $2,557,146 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was made to the Board of Regents of the Nevada System of Higher Education (UEI: WLDGTNCFFJZ3), operating through the University of Nevada, Reno, and will fund research to explore novel targets for gastrointestinal hormones and neuropeptides in the regulation of...
- The University of Vermont & State Agricultural College was awarded a $487,590 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant, titled "Modulation of Gut and Brain Serotonin Signaling by Tryptophan Producing Bacteria", will support research to elucidate the mechanisms by which tryptophan-synthesizing bacteria can enhance...
- This federal Project Grant award of $524,837 from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) is supporting research to investigate the role of enteric glial mechanotransduction and the impact of mechanical stress on postoperative ileus (POI) and postoperative gastrointestinal dysfunction (POGD). The research aims to better understand the pathogenic mechanisms of POI in...
- This Project Grant award, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), aims to investigate the role of the MRGPRX4 receptor in mediating bile acid-induced activation and sensitization of esophageal nociceptive C-fibers. The $565,338 award will support a 5-year research project at The Johns Hopkins University to characterize the expression of MRGPRX4 in...
- This Project Grant award of $554,874 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research at Northern Illinois University to investigate the role of the gut-brain-microbiota axis in the development of inflammatory bowel disease (IBD) induced by long-term stress. The key objectives are to determine how prolonged social isolation and IBD induction affect the gut microbiome of...
- This $168,296 Project Grant was awarded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), to Weill Medical College of Cornell University. The grant supports a 5-year research career development program focused on investigating the role of a key enzyme in group 3 innate lymphoid cells (ILC3s) that regulates gut physiology. The central hypothesis is that ILC3s possess...
This $136,025 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research at New York University (NYU) to investigate the impact of gut epithelial serotonin on the function of afferent neurons and visceral pain signaling. The goal is to determine how modulation of epithelial serotonin could be leveraged as a potential pain therapy for irritable bowel syndrome, a prevalent disorder affecting over 11% of the global population. The 5-year project period runs from September 2025 through July 2030 and involves using electrophysiology, single cell analysis, and biophysical assays to assess how availability of epithelial serotonin regulates the activation and serotonin receptor expression/function of the extrinsic primary afferent neurons that transmit visceral pain signals.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $136.0k | 9/12/25 |