Project Grant R01DK142077
- The National Institutes of Health National Institute of Diabetes and Digestive and Kidney Diseases awarded a $152,205 Project Grant to The Regents of the University of California San Francisco under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant funds research to investigate how vagal sensory neurons regulate autonomic responses to achieve metabolic homeostasis, and how downstream neuronal circuits in the nucleus tractus solitarius integrate...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $765,701 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to Beth Israel Deaconess Medical Center, Inc. (Bidmc) in Boston, Massachusetts. The grant, titled "Mapping Mechanosensory Circuits from the Bladder to Barrington's Nucleus," will fund research to explore the neural circuits that encode bladder fullness and control urination. The project...
- This Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) provides $594,956 to the University of South Florida to conduct research on the mechanisms underlying stretch-evoked activation of esophageal vagal afferents. The goal is to determine the mechanosensitive channels and sodium channels responsible for transducing esophageal stretch into vagal afferent...
- The federal Project Grant award for $236,250 from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847), titled "Nutrient Regulation of the EEC-Vagal Network", will support research conducted by The Ohio State University to study the molecular mechanisms and environmental factors regulating the connection between enteroendocrine cells (EECs) and the vagal sensory nerve in the intestine. The proposed study will use zebrafish models and in vivo imaging to...
- This $2,557,146 Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The award was made to the Board of Regents of the Nevada System of Higher Education (UEI: WLDGTNCFFJZ3), operating through the University of Nevada, Reno, and will fund research to explore novel targets for gastrointestinal hormones and neuropeptides in the regulation of...
- This Project Grant award, valued at $747,133.00, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research by the Monell Chemical Senses Center to behaviorally, physiologically, anatomically, and molecularly characterize a population of neurons in the nucleus tractus solitarius (NTS) that express glucagon-like peptide-1 receptors (GLP1R) and...
- This $136,025 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (CFDA 93.847 - Diabetes, Digestive, and Kidney Diseases Extramural Research program) supports research at New York University (NYU) to investigate the impact of gut epithelial serotonin on the function of afferent neurons and visceral pain signaling. The goal is to determine how modulation of epithelial serotonin could be leveraged as a potential pain therapy for irritable bowel...
- This $2,560,698 federal Project Grant award was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research to investigate the mechanisms by which animals learn about the nutrient content of foods and the neural pathways involved, with a particular focus on the lateralization of dopamine release in the brain. The research aims to reveal how...
- This Project Grant award, totaling $502,233, was provided by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the Regents of the University of Michigan to investigate neuron populations in the nucleus of the solitary tract (NTS) that mediate the aversive and non-aversive suppression of food intake. The research aims to further...
- This $769,097 Project Grant was awarded on September 5, 2025 by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). The grant supports research conducted by the Pennington Biomedical Research Center in Baton Rouge, Louisiana to investigate a novel brain-to-pancreatic islet neural circuit that regulates glucose homeostasis. The research aims to establish the physiological...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), through its Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded a $784,966 project grant to Brandeis University to investigate the sensory functions of pharyngeal enteric neurons in the nematode C. elegans. The 5-year project, starting on Sep 15, 2025 and ending on Jun 30, 2030, aims to study how enteric neurons detect and respond to internal chemical and mechanical cues, and how this sensory integration influences feeding behavior and physiological adaptation. The research focuses on three specific sensory modalities perceived by the enteric nervous system: salt-sensing, bacterial metabolite sensation, and proprioceptive sensing of foregut peristalsis. The project will elucidate the molecular mechanisms and circuit-level functions underlying these interoceptive processes, with the goal of improving understanding of how enteric nervous systems regulate diverse internal signals and their dysfunction contributes to metabolic, gastrointestinal, and neurological disorders.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $785.0k | 9/15/25 |