Project Grant R01DK137812
- Federal Project Grant Award Summary Duke University's Office of Research Administration received a $686,184 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective July 1, 2026 through June 30, 2031. The award funds research into the transcriptional and environmental regulation of lysosome-rich enterocytes (LREs), specialized absorptive cells in the neonatal ileum...
- This Project Grant award from the National Institute of General Medical Sciences (NIGMS) under the Biomedical Research and Research Training program (CFDA 93.859) is providing $414,000.00 to Lewis & Clark College from August 1, 2024 to July 31, 2027 to investigate the role of lipid metabolism in the biogenesis of lysosome-related organelles (LROs). The research aims to gain a better understanding of the processes controlling LRO morphology by studying the ACDH-11 protein and its...
- Federal Grant Award Summary Baylor College of Medicine received a $150,426 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865), effective July 1, 2026 through July 15, 2029. This award funds research into osteoclast dysfunction and juvenile osteoporosis in Lysinuric Protein Intolerance (LPI), a rare inborn error of metabolism caused by loss-of-function variants in the SLC7A7...
- Summary Boston Children's Hospital received a $133,500 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded July 6, 2026, with completion targeted for April 30, 2028. The two-year research project investigates integrin αVβ6-mediated activation of latent transforming growth factor beta 2 (TGF-β2) as a driver of renal fibrosis and explores this pathway as a...
- The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Columbia University's Health Sciences Division a $123,375 Project Grant under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on February 15, 2026, with completion targeted for January 31, 2028. The grant funds research investigating epithelial cell biology in preclinical mouse models of early-onset eosinophilic esophagitis (EOE), a leading cause of esophageal disease in...
- This $414,390 National Science Foundation project grant supports research at Eastern Michigan University to advance understanding of autophagy, a cellular recycling and protection process. Funded under the NSF Biological Sciences program (CFDA 47.074), the three-year award beginning in February 2023 will investigate the molecular mechanisms that drive formation of the autophagosome, a vesicle that degrades cellular cargo. Researchers will study proteins involved in conjugating the ATG8 protein...
- Federal Project Grant Award Summary Award: Cellular Mechanisms of MYO7A in the Retina Funding Agency: National Eye Institute Program: Vision Research (CFDA 93.867) Award Date: April 15, 2026 Completion Date: March 31, 2030 Total Obligated Funding: $590,839.00 Prime Recipient: The Medical College of Wisconsin, Inc. Sub-Recipient: University of California, Los Angeles The National Eye Institute is funding a multiple-principal-investigator research project conducted by The Medical College of...
- The University of California, San Francisco (UCSF) received a $2.78 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) awarded September 15, 2025. The four-year project, concluding September 14, 2029, focuses on advancing understanding of Hirschsprung disease (HSCR), a severe congenital gastrointestinal anomaly resulting from the absence of intrinsic...
- Federal Project Grant Award Summary The Children's Hospital of Philadelphia Research Institute received a $836,942 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 15, 2025, with completion targeted for July 31, 2030. The grant supports basic biomedical research investigating the molecular mechanisms underlying intestinal epithelial...
- Federal Grant Award Summary The University of Arizona received a $249,000 Project Grant from the National Institute of Child Health and Human Development (NICHD) under the Child Health and Human Development Extramural Research program (CFDA 93.865) for the period May 1, 2026 through April 30, 2029. This award funds basic research to characterize the transcriptional regulation and function of BEST4+ cells, a newly discovered intestinal cell type that is significantly depleted in inflammatory...
INVESTIGATING ENDOCYTIC MECHANISMS IN LYSOSOME RICH ENTEROCYTES - ABSTRACT NUTRIENT ABSORPTION IN THE NEONATAL MAMMALIAN GUT RELIES ON INTRACELLULAR DIGESTION BY A POPULATION OF ENTEROCYTES KNOWN AS VACUOLATED OR NEONATAL ENTEROCYTES. RECENTLY, WE SHOWED THESE CELLS ARE CONSERVED BETWEEN ZEBRAFISH AND MAMMALS AND ARE SPECIALIZED IN THE UPTAKE AND DIGESTION OF DIETARY PROTEINS. AS THESE CELLS POSSESS A PROMINENT LYSOSOMAL VACUOLE AND ARE PRESENT IN NON-MAMMALIAN VERTEBRATES SUCH AS FISH, WE REFER TO THEM AS LYSOSOME RICH ENTEROCYTES (LRES). IN OUR PREVIOUS STUDIES, WE FOUND THAT PROTEIN UPTAKE IN ZEBRAFISH AND MOUSE LRES IS MEDIATED BY A SCAVENGER RECEPTOR COMPLEX COMPOSED OF CUBILIN (CUBN), ITS TRANSMEMBRANE PARTNER AMNIONLESS (AMN), AND THE ENDOCYTIC ADAPTOR DAB2. HOWEVER, THE CELLULAR MECHANISMS THAT ALLOW LRES TO INTERNALIZE CARGO FROM THE INTESTINAL LUMEN AT AN ASTOUNDING RATE ARE UNKNOWN. HERE, WE WILL LEVERAGE THE EXPERIMENTAL ADVANTAGES OF THE ZEBRAFISH SYSTEM AND THE CONSERVED BIOLOGY OF LRES TO INVESTIGATE THE ENDOCYTIC MACHINERY THAT ALLOWS THESE CELLS TO SUPPORT DIETARY PROTEIN ABSORPTION IN THE INTESTINE. SPECIFICALLY, WE WILL ELUCIDATE THE MECHANISMS REGULATING A SPECIALIZED FORM OF CLATHRIN MEDIATED ENDOCYTOSIS THAT CONFERS LRES A HIGH CAPACITY FOR LUMINAL PROTEIN UPTAKE.
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $555.6k | 7/7/26 | ||
| Not listed | $555.6k | 6/26/25 | ||
| Not listed | $555.6k | 7/18/24 |