Project Grant R03DK145963
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded The Trustees of Columbia University in the City of New York a $784,280 Project Grant effective September 15, 2025, through July 31, 2030, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847). This research initiative investigates post-transcriptional modifications in esophageal basal cells, with specific focus on the role of METTL3/14...
- Federal Grant Award Summary Cincinnati Children's Hospital Medical Center received a $2,086,360 Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded September 11, 2025, with completion targeted for September 10, 2029. The award funds research investigating the role of nucleotide-binding oligomerization domain-containing 2 (NOD2) genetic variants in...
- Federal Grant Award Summary Vanderbilt University Medical Center received a $1.22 million Project Grant from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), awarded March 15, 2025, with completion targeted for January 31, 2030. The research investigates the role of glutathione peroxidase 3 (GPX3) in regulating esophageal epithelial remodeling, subepithelial fibrosis, and...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded the University of Utah $183,600 through its Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) on July 15, 2025, with completion anticipated by May 31, 2030. This K23 Patient-Oriented Mentored Award supports a structured five-year research and career development initiative led by Principal Investigator Dr. Amiko Uchida, an adult gastroenterologist and...
- Federal Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Columbia University's Health Sciences Division a Project Grant of $246,750 under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), with an award date of August 15, 2025, and a completion date of August 14, 2027. This research project investigates the mechanisms of pancreatic inflammation in obesity, specifically examining how obesity affects...
- Federal Grant Award Summary The Johns Hopkins University received a $565,338 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective September 1, 2025, through August 31, 2030. This five-year research initiative investigates the role of the MRGPRX4 bile acid receptor in esophageal nociception and proton pump inhibitor (PPI)-refractory symptoms...
- Federal Project Grant Award Summary Albert Einstein College of Medicine received a $829,319 Project Grant award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847), effective February 1, 2026, through November 30, 2030. The research project will investigate the collaborating factors driving DDX41 (ATPASE Dead-Box Helicase 41) mutant pathology in myelodysplastic syndromes...
- Federal Project Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded a $234,000 Project Grant to the University of Colorado-Denver on September 15, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to investigate the role of AIOLOS in T cell-mediated pathogenesis of inflammatory bowel disease (IBD). The two-year research project (completion date: September 14, 2027) combines translational...
- Grant Award Summary The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Columbia University's Health Sciences Division a $196,460 Project Grant on June 23, 2025, under the Diabetes, Digestive, and Kidney Diseases Extramural Research program (CFDA 93.847) to conduct basic biomedical research addressing obesity-related inflammation. The research investigates how immature neutrophil migration promotes systemic inflammation during obesity and contributes to metabolic...
- Federal Grant Award Summary The National Institute of Allergy and Infectious Diseases (NIAID) awarded The Children's Hospital of Philadelphia Research Institute a Project Grant totaling $3,375,359 under the Allergy and Infectious Diseases Research program (CFDA 93.855) on July 9, 2025. This four-year initiative, extending through June 30, 2029, will advance scientific understanding of eosinophilic esophagitis (EoE), a chronic inflammatory condition of the esophagus triggered by immune...
The National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) awarded Columbia University's Health Sciences Division a $123,375 Project Grant (CFDA 93.847: Diabetes, Digestive, and Kidney Diseases Extramural Research) effective February 15, 2026, through January 31, 2028. This research project investigates epithelial cell biology mechanisms underlying eosinophilic esophagitis (EOE), a leading cause of esophageal disease in children and young adults. The funded research utilizes preclinical mouse models and three-dimensional organoid culture systems to examine basal cell hyperplasia and epithelial barrier dysfunction in early-onset EOE, with particular focus on the role of Yes-Associated Protein 1 (YAP) signaling and related inflammatory pathways. The project delivers basic biomedical research and translational investigation that advances the understanding of disease mechanisms in pediatric EOE. Specific research activities include loss-of-function mouse model studies, proteomic analysis of esophageal epithelial cells, and comparative analysis of patient tissue samples. The research aims to elucidate molecular pathways linking interleukin-13-induced inflammation to basal cell proliferation and barrier dysfunction, potentially leading to improved prevention and treatment strategies for EOE in pediatric and young adult populations.Federal Grant Award Summary
Mod # | Description | ReasonForModification | Federal Obligation | Date |
|---|---|---|---|---|
| Not listed | $123.4k | 2/9/26 |